To obtain the impact of the new crown epidemic on the spatial structure of self-driving tourism flow during the Spring Festival Golden Week, social network and spatial statistical analysis methods are used to integrate road traffic flow big data and travelogue data to analyze the spatial structure characteristics of self-driving tourism flow in Yunnan Province during the Spring Festival Golden Week in 2018 and 2021. The results show that: 1) The self-driving tourism flow in Yunnan Province during the Spring Festival Golden Week in 2021 shows the “dragonfly” spatial clustering characteristics of “two centers, one axis and two wings”, and the new sub-core area of Qujing is added to the core area of Kunming in 2018, and the self-driving tourists are affected by the epidemic. 2) During the Spring Festival Golden Week in 2021, compared with 2018, there is no significant change in the spatial structure of tourism flow into Yunnan from outside the province, but the degree of intermediary centrality of provincial boundary nodes is significantly weakened, and the self-driving tourism flow at Wenshan junction and Lijiang junction decreased by 72.54% and 87.26%. The New Crown epidemic hindered the development of self-drive tours into Yunnan from Guangxi and Sichuan. 3) During the New Crown epidemic, tourists were less willing to visit hotspot cities, and showed overall behavioral preference characteristics of avoiding crowd gathering and focusing on health and safety. Under the New Crown epidemic, the tendency of long-distance self-driving shifts to close distance self-driving between neighboring cities centered on Kunming.