About This Journal

Cardiac and Cardiovascular Research (CCR, ISSN: 2811-0099) is an international, peer-reviewed, open-access journal published online by Asia Pacific Academy of Science Pte. Ltd.

CCR offers an advanced platform dedicated to the research and treatment of diseases related to the heart and blood vessels. This platform integrates the latest medical technologies and research findings. It aims to improve our understanding of the disease, clinical trials, clinical outcomes, and advances in therapies through timely, insightful scientific communication.

This journal makes research outputs publicly available and welcomes different types of articles including original research articles, reviews, perspectives, case reports, etc.

Focus and Scope

Cardiac and Cardiovascular Research (CCR) is a journal dedicated to the publication of original and groundbreaking research in the field of cardiovascular science and medicine. This journal aims to augment the scientific understanding and clinical management of cardiac and vascular pathologies, thereby contributing to advancements in the treatment of these prevalent disease states. Our publication scope encompasses a broad range of basic science investigations as well as cutting-edge clinical research, ensuring that the findings disseminated reach the widest possible audience of researchers and clinicians.

The journal will specifically address the following topics but not limited to:

  • Heart diseases
  • Cardiovascular medicine
  • Disorder of heart
  • Cardiology
  • Coronary artery diseases
  • Diagnosis treatment of heart diseases

For Authors

  • APACSCI upholds the spirit of strict adherence to high ethical standards. This is consistent with APACSCI's mission of publishing high-quality articles and promoting open scientific exchanges globally. APACSCI follows the Ethical Oversight Guidelines of the Committee on Publication Ethics (COPE) in overseeing the publication process, as well as the activities of APACSCI journals, editors, and reviewers.

    APACSCI and all the editors adhere to the following guidelines:

    1. Core Practices and Best Practice Guidelines of the Committee on Publication Ethics (COPE);

    2. Principles of Transparency and Best Practice in Scholarly Publishing developed by the Committee on Publication Ethics (COPE), Directory of Open Access Journals (DOAJ), Open Access Scholarly Publishers Association (OASPA), and World Association of Medical Editors (WAME).

    3. Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly Work in Medical Journals from the International Committee of Medical Journals Editors (ICMJE).

    APACSCI is committed to protecting the privacy of its contributors and promises not to disclose personal information to third parties without permission, unless for necessary purposes of the publishing process or required by law.

    APACSCI takes allegations of misconduct (refer to the Misconduct Policy for more details) seriously and will launch an immediate investigation by a group of investigation members. Decisions will be made by the investigation group based on clear evidence, and the authors will be informed. If there is any appeal against the decision, it must be made to the publisher within 14 days of the decision date, or else actions will be taken after 14 days. The decision on the appeal is final.

    Any complaints and appeals against APACSCI journals and editors can be directed to the publisher at editorial_office@apacsci.com, and APACSCI follows COPE guidelines in handling all complaints and appeals.

    Research Involving Human Subjects

    Authors who carry out research involving humans must declare that their studies followed the WMA Declaration of Helsinki. They must obtain approval from the concerned research ethics committee before carrying out the research and accept the monitoring by the committee. During the submission stage, authors are required to attach a statement containing the name of the ethics committee, the approval code, etc.

    Informed consent to participate in the research must be obtained from all human subjects or their guardians. A statement on the consent to participate should also be included during submission. If there is no need for informed consent, authors must provide the name of the ethics committee and the reason for the absence of the need for informed consent.

    Human subjects' right to privacy right is inviolable. Authors should not disclose any identifying information, including but not limited to names, initials, contacts, and medical record numbers, unless the absence of such information may influence the interpretation of the research. In addition, written informed consent for publication from the participants should be obtained. If participants are vulnerable, informed consent should be given by their guardians. Authors must inform the participants if pictures of their bodies (e.g., faces) have to be included in the manuscript and receive consent for publication. In the case of deceased human subjects, their next of kin or legal representative should be asked for consent.

    Research Involving Animal Subjects

    All studies involving animals should be approved by an ethics committee before the research is conducted. If ethical approval is not required by national laws, exemption from the ethics committee, the name of the ethics committee, and the reason should be provided by the authors during submission.

    The following guidelines can be helpful for authors in upholding high ethical standards and avoiding submission rejection

    APACSCI applies The ARRIVE Essential 10: Compliance Questionnaire for evaluating comparative experiments in living animals. Authors can also use it as a checklist.

  • Based on the guidelines of the International Committee of Medical Journal Editors (ICMJE), authorship should be limited to those who meet the following four criteria:

    1. Contributed substantially to the conception or design of the manuscript or the acquisition, analysis, or interpretation of data for the manuscript; AND
    2. Drafted the manuscript or reviewed it critically for significant intellectual content; AND
    3. Have final approval of the version to be published; AND
    4. Agreed to be responsible for the manuscript in ensuring that problems relating to the accuracy or completeness of any part of the manuscript are appropriately investigated and resolved.

    Individuals who do not meet the above four criteria should not be listed as authors but should be acknowledged. Authors should disclose whether artificial intelligence (AI)-assisted technologies were used in the preparation of their manuscripts and how they used them. Authors should also report the use of AI for writing assistance in the Acknowledgment section. AI tools should not be used in sections that rely on human intellectual analysis, such as data interpretation and conclusion summarization.

    Changes to Authorship

    Authorship changes (addition, deletion, or rearrangement of author names) should be made before the acceptance of the manuscript. Confirmation from all authors (including existing authors and author(s) to be added and/or removed) should be provided to the editorial office of the journal, together with the reason for such changes. Changes can be made after the approval of the journal.

  • Authors are required to declare any potential conflicts of interest (financial or non-financial). Any agreements with study sponsors (for-profit or non-profit), such as those that interfere with the authors' access to the study's data or with the authors' ability to analyze or interpret the data and to publish manuscripts independently according to their own decision, should be avoided by authors at all costs.

    APACSCI also requires reviewers and editors to declare any (potential) non-financial conflicts of interest and declare any unpaid roles or relations that may influence the decision on the manuscript's publication. These include, but are not limited to, unpaid roles in a governmental or non-governmental organization, unpaid roles in an advocacy or lobbying organization, and unpaid advisory positions in a commercial organization.

    In addition, reviewers and editors must disclose any association that poses a conflict of interest in connection with the manuscript. Examples are personal or work-related relationships with one of the authors or the reviewer is on the authors' avoidance list.

  • Following COPE guidelines, APACSCI will not accept any misconduct behaviors that may mislead researchers.

    Plagiarism

    Plagiarism is not acceptable. Using the content from one's own previously published articles without proper citation is also considered plagiarism. APACSCI adopts Crossref Similarity Check (powered by iThenticate) for checking the originality of submissions. Manuscripts with a high similarity index may be rejected.

    Fabrication and Falsification

    Fabrication and falsification of data or images will mislead researchers. APACSCI strongly opposes such practices and will reject suspicious submissions.

    Duplicate Submission

    Duplicate submission of a manuscript that has been published or submitted to other journals at the same time will not be considered.

  • The language of all manuscripts must be English (either British or American) and non-English words should be used sparingly. Poor English may lead to article rejection. Authors are encouraged to seek language polishing by a native English speaker or a professional editing service.

  • Correction

    Authors are responsible for approving the final version of their manuscript and they should avoid any errors prior to publishing. In the case of errors that occur in a published article and have no influence on research results, APACSCI will issue a correction/erratum.

    Authors, readers, and editors are encouraged to report any errors found in published papers. Please contact the editorial office of the particular journal.

    Retraction

    Based on COPE guidelines, the following conditions can lead to the retraction of a published article:

    • Unreliable findings
    • Plagiarism
    • Published elsewhere without proper attribution to previous sources, disclosure to the editor, permission to republish, or justification
    • Containing material or data without the authorization for use
    • Infringement of copyright, violation of privacy, or other legal issues
    • Unethical research
    • Dubious peer review processes
    • Failing to disclose a major competing interest

    If any of the above misconduct proved to be true, a retraction notice will be issued with the reason, while the PDF of the retracted article will be watermarked with "Retracted". The journal editors will inform the authors of the retraction.

    Paid Article Processing Charges will not be refunded to the authors if retraction occurs.

    Withdrawal

    Although not encouraged, authors can initiate the withdrawal of their submission before and during the peer review process by providing the reason. However, authors should note that a penalty fee of US$200 will be imposed for the withdrawal of a submission undergoing the peer review process due to the spent efforts on the evaluation of the manuscript by the editors and reviewers. Upon the approval of submission withdrawal, the submission will be removed from the journal's operation system, and the authors be informed.

    Accepted articles and articles in press may also be withdrawn due to infringements of professional ethical codes (similar reasons to those for retraction).

  • APACSCI allows authors to post preprints of the manuscript of their original research articles (limited to only this type of article) on community preprint servers, such as arXiv, bioRxiv, and PeerJ Preprint, prior to or simultaneous with their manuscript submission to APACSCI journals. Authors retain the copyright of the manuscript posted on a preprint server.

    Authors should inform the editors of the preprint version of their submitted manuscript in a cover letter, as well as provide any associated accession numbers or DOIs. Revised versions per the result of the peer review process and accepted versions for publication should not be posted on a preprint server.

    Upon publication of the article, APACSCI encourages authors to link the article in the preprint server to the journal site, so as to guide readers to access and refer to the final version of the article.

  • Authors should read the "Author Guidelines" before making a submission, and make sure that the manuscripts were written in accordance to the style and specifications of the journal's policy.

    All manuscripts submitted to Cardiac and Cardiovascular Research are subject to rigorous peer review. Prior to peer review process, the manuscripts will be screened for acceptable English language, novelty and relevance to the Focus and Scope of the journal.

    Any manuscripts submitted to Cardiac and Cardiovascular Research will be treated as confidential materials. The manuscripts will not be disclosed to anyone except individuals such as editorial staff, reviewers and editors who participate in the initial screening, review, processing and preparation of the manuscript for publication (if accepted).

    A manuscript would not be accepted if it has been published or is currently under consideration for publication in any other journals. The authors are required to notify the editorial team if the findings and data in their submissions have been presented in conferences.

  • The opinions, statements, methods, results, and data in APACSCI's published articles are those of the authors and do not reflect the opinions of APACSCI and its editors. APACSCI disclaims responsibility for any injury to people or property resulting from any ideas, methods, or products referred to in the articles or advertisements.

  • Authors contributing to APACSCI journals retain the copyright and grant a publishing license. All articles are published under the Attribution 4.0 International (CC BY 4.0) or Attribution-Noncommercial 4.0 International (CC BY-NC 4.0) license. These licenses allow anyone to download and read the articles for free, and reuse the material contained in the articles with proper acknowledgment and citation (for articles under CC By-NC 4.0, using them for commercial purposes is prohibited).

    Regarding the default license used, authors should carefully check the policies of the journal to which they would like to submit their manuscript. Authors with no special requests will be deemed to agree to the default license.

    It is the responsibility of authors to obtain permission to reuse material previously published under a more restrictive license from the copyright holder before the submission stage. These may include figures, tables, and schemes.

  • The publisher requests that this journal only consider advertising applications that are relevant to the contents of the journal, if available.

    1. The publisher (APACSCI) reserves the right to accept or refuse advertising. The Journal Editorial Office will evaluate whether to accept the request.
    2. Advertisements must comply with relevant rules and laws in the country where they will appear.
    3. Advertisements should be legible and advertisers identifiable. Sponsors may not arrange or influence editorial decisions including any content in the journal.
    4. Advertisements must not be misleading or deceptive. Advertising content must not contain indecent, offensive, or sensitive information (such as politics, ethnicity, gender, religion, etc.).
    5. APACSCI disclaims responsibility for any damages resulting from advertisements in its journals. The publisher or journal does not accept advertisements for products or services known to be harmful to health/science or contrary to academic principles.
    6. Unless the advertiser requests differently, all advertisements posted by the publisher will be displayed at random. Special requests need to be addressed to the publisher, who will make a final decision on a case-by-case basis within 7 working days.
    7. Advertising is independent, with journal web features and academic content free from all advertising and product interference.
    8. Once an advertisement is posted online, it will be removed from the journal's website at any time if the Editor-in-Chief or publisher requests that it be removed.

    For any advertisement queries or appeals/complaints, please contact APACSCI at editorial_office@apacsci.com.

  • APACSCI's publishing model is open access. Open access enables readers to freely access and download articles immediately after publication online. APACSCI charges authors article processing charges (APCs) so as to cover operation costs, such as those arising from the evaluation and production processes. APCs should be paid upon the acceptance of articles and ahead of publication.

    APCs of Cardiac and Cardiovascular Research are US$800.

    Waiver and Discount Policy

    APACSCI believes there should be no barriers to the dissemination of knowledge, and thus APACSCI offers APC waivers and discounts to authors from low-income countries and authors with special circumstances. Authors should write to the editorial office of the specific journal to apply for waivers and discounts. The decision to approve such applications is made by the editorial office on a case-by-case basis.

    • All the articles published online will be archived by Portico for long-term digital preservation.
    • Authors are encouraged to self-archive the final version of their published articles into institutional repositories (such as those listed in the Directory of Open Access Repositories).
    • Authors are also encouraged to use the final PDF version published on the website of Cardiac and Cardiovascular Research.
     
    Cardiac and Cardiovascular Research (CCR) has be indexed by several world-class abstracting/indexing databases:
    • Google Scholar
    • Scilit
    • EuroPub
     
    We aim to be included in the first-class academic databases in the world, such as WoS, Scopus, Inspec, and EI.

  • 1. What is a Special Issue?

    A Special Issue Program has been launched by Asia Pacific Academy of Science Pte. Ltd. A Special Issue is a collection of research hotspots or topics in a specific field. Guest Editors who are experts in this discipline, have the responsibility to drive the special issue program. Manuscripts accepted will both be ordered/archived in a regular volume/issue and a special issue.

    Benefits of Special Issue

    • Being more quickly discovered and cited.
    • Promoting academic exchanges in this field.
    • Avoiding repetition of topics.
    • Disseminating the latest achievements.
    • Broadening the visibility and maximizing the impact of a certain field so that more experts could focus on the topic.

    Benefits of being Guest Editors

    • Expanding the popularity.
    • Initiating the communication and establishing co-operatives ties faster.
    • Learning the latest research.
    • Publishing one article without any APCs as the privilege.

    2. How to drive a Special Issue?

    There are two ways to obtain a special issue proposal.

    • Guest Editors will be invited by assistant editors to submit a professional proposal.
    • Authors and readers are welcomed to submit proposals via emailing to editorial-ccr@apacsci.com, and EiC will evaluate them for the viability and suitability for this journal.

    Preparation for a proposal

    A great topic is the crucial element for success. Each candidate topic will be selected by EiC for considering whether it is consistent with the scope of this journal. Hot topics are usually considered to be more attractive.

    A proposal should include the necessary information:

    • List of Guest Editors
    • Types of manuscript
    • Main topics
    • Submission deadline
    • Keywords

    3. Special Issue Ethics

    APACSCI abides to the Code of Conduct of the Committee on Publication Ethics (COPE) and Best Practice Guidelines in all the editorial process. Each new submission must follow the journal's Editorial Policies, and any potential unethical manuscripts will not be passed to the nest stage. APACSCI promises to protect the confidentiality of all submissions unless the publishing needs. All the editors and reviewers must strictly abide by the Conflict of Interest of the journal, and they are asked to inform the Editorial Office if any potential conflicts of interest exist, and then, the Editorial Office may consider to change the editor or reviewer. As authors, they have the right to provide a list of avoided experts. Please appeal to editorial-ccr@apacsci.com for any requests related to manuscript promotion.

    4. Workflow of a Special Issue

    Manuscripts should be submitted to Open Journal Systems (OJS) and go through a double-blinded peer-reviewed process (refer to Peer Review Policy).

  • Researchers using an Artificial Intelligence Generated Content (AIGC) tool/service to directly generate the manuscript text must provide clear disclosures and statements, otherwise it will be considered academic misconduct. The journal allows the use of an AIGC tool/service for text embellishment and automatic sorting of references, but does not recommend the use of the AIGC tool/service in the thinking and concluding sessions of human involvement such as data analysis and interpretation, opinion hypothesis and conclusions, and the AIGC tool/service cannot fulfill the role of a textual author. If any part of the manuscript was written using an AIGC tool/service, it must be described openly, transparently, and in detail in the Methods or Acknowledgments section, for example:

    "In the preparation of this work, the authors used the [name of the specific AIGC tool/service] to [purpose of use: e.g., literature research/text embellishment, etc.]. After using this tool/service, the authors reviewed and edited the content as needed, and take full responsibility for the content of the publication."

  • Cardiac and Cardiovascular Research adopts and follows the rules of International System of Units (SI) for physical quantities and units of measurement. For example:

    • Quantities including time, length, mass, electric current, etc., should be written as s (second), m (metre), kg (kilogram), A (ampere) after metric numbers.
    • Adopt unified format for the same unit of measurement.

  • According to the data and reproducibility of COPE, APACSCI encourages authors to share associated data, code, and materials, register clinical trials, and use standardized guidelines to achieve greater transparency, replicability, and trust in scientific findings. Thus, authors are encouraged to deposit datasets in a data repository; the premise is that this data is not suitable for submission as online supplementary files. Authors who have deposited raw data in community database repositories are encouraged to include a data availability statement in their manuscript. The statement should provide information about the availability of the research data and any limitations or conditions associated with accessing the data, except for reasonable controls related to human privacy or biosecurity. Reusing scientific data can offer great potential for further scientific and economic development.

    • Data Sharing

    For data shared, the FAIR Data Principles should be followed, which guides that (meta)data are assigned a globally unique and eternally persistent identifier. Authors should cite the correct sources. Collaborative practices should be implemented across journals and institutions to monitor and ensure the scientific validity and credibility of overall research practices. Authors are encouraged to prioritize the use of original data from their study and provide supporting data such as accessible data sources as early as possible.

    Regarding data involving confidentiality/privacy/personal privacy, etc., authors are advised to do their best to hide identifiable sensitive information and to share data in strict accordance with mandatory guidelines for the discipline.

    According to the guidelines of COPE regarding unpublished data, the journal will address concerns to the data provider regarding the scientific rigor of an unpublished dataset. The journal will contact the corresponding author, and request comments on the concerns, supporting documentation as needed, and information about any other affected content. Following the guidelines regarding published data, if there is a manuscript associated with a published dataset whose scientific rigor is in doubt, the journal will contact any implicated journals that have published results from the suspicious dataset, summarizing the issue and actions taken to date. Authors must respond with a satisfactory update. If the issues are major or impact the conclusions of the manuscript, the author(s) should withdraw the manuscript or the journal will reject the submission.

    • Data Citation

    Authors are encouraged to cite any datasets deposited in external repositories mentioned in their manuscript in the references. For previously published datasets, authors should cite both the published research article and the source of the dataset itself. Journal editorial staff will check and enforce proper data citation before publication.

    Data citations should include the minimum information recommended by DataCite:

    1)      Author(s)

    2)      Year of publication/release

    3)      Title

    4)      Publisher/repository or archive name

    5)      Persistent identifier (e.g., DOI)

     

    • Data Repository

    Authors are encouraged to deposit their datasets in the relevant community dataset repository, or a general dataset repository (including any generalist data repository provided by a university, funder or institution for its affiliated researchers) that aligns with the specifications and requirements of their discipline could be selected. The publisher recommends that authors select a repository with a DOI (Digital Object Identifier) to ensure that the referenced dataset can be linked to consistently.

    Authors could explore online resources for lists of registered data repositories through FAIRsharing.org and re3data.org.

    Here are some examples of generalized dataset repositories:

  • The Journal complies with the standards of WHO ICPRP and ICMJE regarding to clinical trial registry. According to the WHO ICPRP and ICMJE, a clinical trial is any research study that prospectively assigns human participants or groups of humans to one or more health-related interventions to evaluate the effects on health outcomes. Clinical trials may also be referred to as interventional trials. Interventions include but are not restricted to drugs, cells and other biological products, surgical procedures, radiologic procedures, devices, behavioural treatments, process-of-care changes, preventive care, etc. This definition includes Phase I to Phase IV trials.

    The Journal requires that all research protocols involving a first clinical trial be registered in a public clinical trial registry (except those that have already been published). WHO regards trial registration as the publication of an  internationally-agreed set of information about the design, conduct and administration of clinical trials. This requirement is not only conducive to increasing the transparency of clinical trial information and reducing publication bias, but also conducive to guaranteeing the quality of clinical trials, increasing the standardization of the trial process and the credibility of the test results.

    Authors whose manuscript involve clinical trials, should demonstrate the trial registry information in a cover letter, such as the name of trial registry, and the unique ID number assigned by the Primary Registry to this trial. Meanwhile, authors also should mention the trial registry information at the “Materials and Methods” section with appropriate references. Secondary data analyses of primary (parent) clinical trials should not be registered as separate clinical trials, but instead should reference the trial registration number of the primary trial.

    Some primary registers meeting the specific criteria of WHO Registry Network and the requirements of the ICMJE, include International Clinical Trials Registry Platform (ICTRP), ClinicalTrials.gov.

  • Author Guidelines


    Before submitting to the journal, authors should read through the author guidelines for preparing their manuscript. Starting in 2024, a new layout style will be applied, so please download the new manuscript template. 


    Manuscript Format


    The manuscript should be in MS Word or LaTeX format. The language of all manuscripts must be English (either British or American) and non-English words should be used sparingly. Poor English may lead to article rejection. Authors are encouraged to seek language polishing by a native English speaker or a professional editing service.


    Article Types


    Please refer to the Section Policy for choosing an appropriate type.


    Cover Letter


    Authors should attach a cover letter together with the article text. A cover letter should contain a brief explanation of the significance of their work and the intention of doing the work. If the work involves the human and animal research, authors should provide the Informed Consent Statement or Ethical Approval ID attached with cover letter. The cover letter is confidential and will be read only by the editors. It will not be seen by the reviewers.


    Article Title


    Titles should be no more than 50 words, with significant and attractive information for readers. Titles should not include uncommon jargons, abbreviations, and punctuation.


    List of Authors


    The list of authors should be arranged based on the level of their contribution, with the major contributor listed first. Corresponding authors should be marked with an asterisk (*). Affiliation information should be provided with the following elements: department, institution, city, postal code (if available), and country. The email address of at least one corresponding author must be provided. All authors must approve the final version of the manuscript and agree with the submission. For more information about authorship, please refer to our Authorship Policy.


    Abstract and Keywords


    Depending on the article type, an abstract should be provided, which gives a concise summary of the article. It is usually a single paragraph of about 200–250 words maximum. Between 5–8 keywords should be included. Words and phrases in article titles should be avoided as keywords.


    Text


    The text of manuscripts should be in MS Word or LaTeX format. Original research articles should include the Introduction, Materials and Methods, Results, Discussion, and Conclusion (optional) sections.


    Section Headings


    Headings are used to indicate the hierarchy of the sections of the text. No more than three levels of headings should be employed. The first level of heading should be numbered as 1., 2., 3., 4. in boldface. Likewise, the second and third levels of headings should also be in boldface, for example, 1.1., 1.2., 1.1.1., 1.1.2.


    Introduction


    The introduction should provide a background that gives the broad readership an overall outlook on the field and the research performed. It pinpoints a problem and states the significance of the study. The introduction can conclude with a brief statement on the aim of the work and a comment about whether that aim was achieved.


    Materials and Methods


    This section provides the general experimental design and methodologies used. The aim is to provide enough details for other investigators to fully replicate the experiments. It is also to facilitate a better understanding of the results obtained.


    Results


    This section can be divided into subheadings. This section focuses on the results of the experiments performed.


    Discussion


    This section should provide the significance of the results and identify the impact of the research in a broader context. It should not be redundant or similar to the content of the Results section.


    Conclusion (Optional)


    The conclusion section can only be used for interpretation, and not be used to summarize information already presented in the text or abstract.


    Figures and Tables


    Figures (photographs, images, graphs, charts, and schematic diagrams) and tables should be referred to within the main text and numbered consecutively as Figure 1, Figure 2, Table 1, Table 2, etc. They should be placed as close as possible to where they are first cited and center-aligned. Both figure captions and table captions should be center-aligned, with figure captions set underneath the figures and table captions above the tables. When captions are longer than one line, they should be left-aligned.


    Figures can contain multiple panels. They should be numbered by Latin letters with parentheses, e.g., (a), (b), (c), or (A), (B), (C), placed below the image or within the image.


    Tables should be in MS Word/Excel table format. Tables containing too much information can be provided as supplementary material.


    In the main text, all figures and tables should be cited, e.g., "Table 1 indicates…", "Figures 1 and 2 shows…", and "Figure 1a,b shows…".


    Lists and Equations


    Both bulleted lists and numbered lists are acceptable (refer to the template). Equations should be center-aligned and equation numbers should be right-aligned. If cited in the text, equations should be labeled with numbers in parentheses, e.g., Equation (1).


    In-Text Citations


    All bibliographical references that make an important contribution to the article should be numbered according to the appearance order. When cited in the text, the number should be placed in square brackets, for example:



    • Negotiation research spans many disciplines [3,4].

    • This effect has been widely studied [1–5,7].


    Appendix (Optional)


    An appendix provides information supplementary to an article and is included at the end of the article after the References section and it should start on a new page. For one appendix, it is designated as "Appendix"; for more than one appendix, they are designated "Appendix A", "Appendix B", etc.


    An appendix should be cited in the main text. Tables, figures, and equations should be started with the prefix A (i.e., Figure A1, Figure A2, Table A1, etc.).


    Back Matter


    The sequence of back matter elements in an article is listed below. There is no numeral label for back matter headings. Some of these elements are optional.


    Supplementary Materials (Optional)


    The Supplementary Materials section provides a short description of the supplementary materials. One or more individual supplementary files are allowed and should be submitted in Step 4 during submission. These materials are relevant to the manuscript but remain non-essential to readers' understanding of the article's main content. Please ensure the names of such files contain "suppl. info". Videos may be included in this section.


    Author Contributions


    For original research articles, this section is required, except when there is only one author for the article. The contribution of each co‐author should be reported in this section.


    The following statements should be used "Conceptualization, XX and YY; methodology, XX; software, XX; validation, XX, YY and ZZ; formal analysis, XX; investigation, XX; resources, XX; data curation, XX; writing—original draft preparation, XX; writing—review and editing, XX; visualization, XX; supervision, XX; project administration, XX; funding acquisition, YY. All authors have read and agreed to the published version of the manuscript."


    Funding (Optional)


    Authors can acknowledge financial support in this section, which is NOT mandatory. If authors provide a funding statement, it should be in the same style as the template.


    For example:


    "This research was funded by [name of funder] grant number [xxx]" and "The APC was funded by [XXX]". Please check carefully that the details given are accurate and that the standard spelling of the funding agency's name in https://search.crossref.org/funding is used, as any errors may affect the authors' future funding.


    Acknowledgments (Optional)


    Authors can acknowledge any support and contribution that cannot be included in the Author Contributions and Funding sections. This section is NOT mandatory.


    Conflict of Interest


    According to our Conflict of Interest Policy, all authors are required to declare all activities that have the potential to be deemed as a source of competing interest in relation to their submitted manuscript. Examples of such activities include personal or work-related relationships and events. Authors who have nothing to declare should add "No conflict of interest was reported by all authors" or "The authors declare no conflict of interest" in this section.


    References


    This section is compulsory and should be placed at the end of the manuscript. Footnotes or endnotes should not replace a reference list. The list of references should only include works that are cited in the text and that have been published or accepted for publication. Personal communications should be excluded from this section.


    The format of author names should be "Last-Name Initial", e.g., David Smith should be written as Smith D.


    Journal


    Journals in English:



    • Author AA, Author BB, Author CC, et al. Title of the article. Journal Name. Year, Volume(Issue) (if available): Firstpage–Lastpage. doi (if available)


    Journals in languages other than English:



    • Author AA, Author BB, Author CC, et al. English title of the article (original language). Journal Name. Year, Volume(Issue) (if available): Firstpage–Lastpage. doi (if available)


    Book


    A book without editors:



    • Author AA, Author BB. Chapter (optional). Title of the Book, Edition (if available). Publisher; Year. pp. Page range (optional).


    A book with editors:



    • Author AA, Author BB. Title of the contribution. In: Editor CC, Editor DD (editors). Title of the Book, Edition (if available). Publisher; Year. Volume (optional), pp. Page range (optional).


    For a translated book, the translators' names should be placed after the editors' names: "Translator AA (translator)" or "Translator AA, Translator BB (translators)".


    If the editors and translators are the same, the format should be as follows:



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    Unpublished Work



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    Online Resources



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APACSCI's publishing model is open access. Open access enables readers to freely access and download articles immediately after publication online. APACSCI charges authors article processing charges (APCs) so as to cover operation costs, such as those arising from the evaluation and production processes. APCs should be paid upon the acceptance of articles and ahead of publication.

APCs of Cardiac and Cardiovascular Research are US$800.

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Latest Articles
Open Access
Article ID: 2729
Abstract
Frequency of occurrence of dry mouth in women with high risk of cardiovascular diseases during the menopause
by Nataliya Emelyanova, Dmitry Emelyanov
Card. Cardiovasc. Res. 2024 , 5(1);   
doi: 10.54517/ccr.v5i1.2729
Abstract Among the risk factors for dry mouth, or xerostomia, are both estrogen deficiency in women during menopause and the use of medications with xerogenic properties. Until now, it has not been clearly determined, whether dryness in the oral cavity in women during menopause is only associated with subjective sensations or is accompanied by qualitative and quantitative changes in mixed saliva. To determine the frequency and nature of xerostomia syndrome in women during menopause with high and extremely high risk of cardiovascular diseases. The study involved 35 patients (with subjective sensations of dryness in the oral cavity) and 20 apparently healthy women. All study participants were questioned for any dental complaints, and the quantitative indicators of the oral fluid were assessed. An individualized oral hygiene complex and a moisturizing gel were prescribed as correction of the subjective signs of xerostomia. The follow-up visit was carried out after 1 month. The patients in natural menopause felt slight subjective manifestations of dry mouth confirmed by objective decrease in salivary secretion; whereas in most cases subjective dryness in the oral cavity is accompanied by normal secretion. The prescribed complex for correction of dental complaints ensures decrease in the subjective signs of dryness, decrease in taste distortion and halitosis.
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Open Access
Article ID: 2696
Abstract
A study of cardio vascular disease prediction and optimization of health care data
by L. Pushpalatha, R. Durga
Card. Cardiovasc. Res. 2024 , 5(1);   
doi: 10.54517/ccr.v5i1.2696
Abstract Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide, accounting for a significant proportion of healthcare costs. It is a major public health concern, and early detection and prevention are critical for reducing its burden. Several risk factors for CVD have been identified, including age, sex, genetics, hypertension, diabetes, smoking, and physical inactivity. Despite the identification of several risk factors, there is still a lack of understanding of the underlying mechanisms that contribute to CVD development. This study aimed to investigate the potential predictors of CVD and identify novel biomarkers that could be used for early detection and prevention. The study explored pre-processing strategies, including Synthetic Minority Oversampling Technique (SMOTE), Z-Score Normalization, and Adaptive Synthetic Sampling (ADASYN), to address class imbalance and enhance model performance. The dataset consisted of medical images labeled with different cardiovascular diseases. By integrating the strengths of Support Vector Machines (SVM) classification and Linear Discriminant Analysis (LDA), Principal Component Analysis (PCA), and PCA with ReliefF feature retrieval methods, the study investigated various feature extraction approaches for classifying cardiovascular diseases.
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Open Access
Article ID: 2361
Abstract
Bartonella quintana endocarditis: A case report
by Majdi Maazoun, Fatma Hammami, Fatma Gassara, Khaoula Rekik, Makram Koubaa, Mounir Ben Jemaa
Card. Cardiovasc. Res. 2024 , 5(1);   
doi: 10.54517/ccr.v5i1.2361
Abstract Endocarditis is a rare and potentially fatal infection of the endocardium. Bartonella endocarditis is an emerging disease that causes serious complications and high rates of mortality. Due to the fastidious nature of Bartonella species and their high degrees of antibiotic susceptibility, cultures of clinical samples most often remain sterile. The best specimens for polymerase chain reaction amplification are seldom available. The diagnosis of Bartonella infections relies mainly on serological methods. We report the case of a 58-year-old woman with dyslipidemia who presented with nocturnal fever, polyarthralgia, sweats and weight loss. The diagnosis of Bartonella endocarditis was confirmed by an indirect immunofluorescence assay. Medical treatment alone was efficient for our patient without any surgery.
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Open Access
Article ID: 1918
Abstract
Diabetes and cardiovascular disease
by Carlos Guamán, William Acosta, Carla Alvarez4, Benhard Hasbum
Card. Cardiovasc. Res. 2023 , 4(2);   
doi: 10.54517/ccr.v4i2.1918
Abstract Diabetes mellitus is one of the main causes of morbidity and mortality worldwide. This group of patients generally represents a population at high or very high cardiovascular risk, which is why early risk stratification is performed, seeking to focus objectively on the pharmacological and nonpharmacological approach with an intensive strategy. Cardiovascular disease represents the main cause of mortality, but in recent years there have been advances in therapeutics that have been shown to reduce major cardiovascular events. This article reviews the interaction between diabetes, cardiovascular disease and its treatment.
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