Asia Pacific Academy of Science Pte. Ltd. (APACSCI) specializes in international journal publishing. APACSCI adopts the open access publishing model and provides an important communication bridge for academic groups whose interest fields include engineering, technology, medicine, computer, mathematics, agriculture and forestry, and environment.
Historically, the heart has been considered a vital organ due to its function as an impeller and aspirating blood pump, allowing the fi siological perfusion to every corner of the human body. However, behind this pump role lies a little-discussed function, that is, the endocrine-metabolic role of the heart, as a hormone synthesizing organ and, because of its pump function, a distributor of hormones foreign to it. Understanding the incidence of peptides synthesized in the heart offers a new perspective on the relevance of the heart in homeostasis and how cardiovascular disease can alter metabolism. The present work aims to review the most current information on the role of natriuretic peptides produced in the heart and their endocrine-metabolic function. These are atrial, brain and C-type natriuretic peptides. It is concluded that the conception of the heart as an organ of endocrine-metabolic regulation, whose hormones are essential for the homeostasis of the organism, is fundamental for the medicine of this century and for future advances in new therapeutic strategies to improve the quality of life of patients.
Cardiac and Cardiovascular Research (CCR, ISSN: 2811-0099) is a peer-reviewed, open-access journal published online by Asia Pacific Academy of Science Pte. Ltd.
CCR offers an advanced platform dedicated to the research and treatment of diseases related to the heart and blood vessels. This platform integrates the latest medical technologies and research findings. It aims to improve our understanding of the diseases, clinical trials, clinical outcomes, and advances in therapies through timely, insightful scientific communication.
This journal makes research outputs publicly available and welcomes different types of articles including original research articles, reviews, perspectives, case reports, etc.
Focus and Scope
Cardiac and Cardiovascular Research(CCR) is a journal dedicated to the publication of original and groundbreaking research in the field of cardiovascular science and medicine. This journal aims to augment the scientific understanding and clinical management of cardiac and vascular pathologies, thereby contributing to advancements in the treatment of these prevalent disease states. Our publication scope encompasses a broad range of basic science investigations as well as cutting-edge clinical research, ensuring that the findings disseminated reach the widest possible audience of researchers and clinicians.
The journal will specifically address the following topics but not limited to:
● Heart diseases ● Cardiovascular medicine ● Disorder of heart ● Cardiology ● Coronary artery diseases ● Diagnosis treatment of heart diseases
For Authors
APACSCI upholds the spirit of strict adherence to high ethical standards. This is consistent with APACSCI's mission of publishing high-quality articles and promoting open scientific exchanges globally. APACSCI follows the Ethical Oversight Guidelines of the Committee on Publication Ethics (COPE) in overseeing the publication process, as well as the activities of APACSCI journals, editors, and reviewers.
APACSCI and all the editors adhere to the following guidelines:
APACSCI is committed to protecting the privacy of its contributors and promises not to disclose personal information to third parties without permission, unless for necessary purposes of the publishing process or required by law.
Complaints and appeals
APACSCI takes allegations of misconduct (refer to the Misconduct Policy for more details) seriously and will launch an immediate investigation by a group of investigation members. Decisions will be made by the investigation group based on clear evidence, and the authors will be informed. If there is any appeal against the decision, it must be made to the publisher within 14 days of the decision date, or else actions will be taken after 14 days. The decision on the appeal is final.
Authors also could express complaints and concerns about delays, extensions, and unreasonable handling procedures during the editing process and the time it takes. The editor-in-chief will be accountable for initiating an investigation into the issue, and the complainant will receive feedback. Reasonable editing procedures will be enhanced.
Any complaints and appeals against APACSCI journals and editors can be directed to the publisher at editorial_office@apacsci.com, and APACSCI follows COPE guidelines in handling all complaints and appeals.
Research Involving Human Subjects
Authors who carry out research involving humans must declare that their studies followed the WMA Declaration of Helsinki. They must obtain approval from the concerned research ethics committee before carrying out the research and accept the monitoring by the committee. During the submission stage, authors are required to attach a statement containing the name of the ethics committee, the approval code, etc.
Informed consent to participate in the research must be obtained from all human subjects or their guardians. A statement on the consent to participate should also be included during submission. If there is no need for informed consent, authors must provide the name of the ethics committee and the reason for the absence of the need for informed consent.
Human subjects' right to privacy right is inviolable. Authors should not disclose any identifying information, including but not limited to names, initials, contacts, and medical record numbers, unless the absence of such information may influence the interpretation of the research. In addition, written informed consent for publication from the participants should be obtained. If participants are vulnerable, informed consent should be given by their guardians. Authors must inform the participants if pictures of their bodies (e.g., faces) have to be included in the manuscript and receive consent for publication. In the case of deceased human subjects, their next of kin or legal representative should be asked for consent.
Research Involving Animal Subjects
All studies involving animals should be approved by an ethics committee before the research is conducted. If ethical approval is not required by national laws, exemption from the ethics committee, the name of the ethics committee, and the reason should be provided by the authors during submission.
The following guidelines can be helpful for authors in upholding high ethical standards and avoiding submission rejection
Contributed substantially to the conception or design of the manuscript or the acquisition, analysis, or interpretation of data for the manuscript; AND
Drafted the manuscript or reviewed it critically for significant intellectual content; AND
Have final approval of the version to be published; AND
Agreed to be responsible for the manuscript in ensuring that problems relating to the accuracy or completeness of any part of the manuscript are appropriately investigated and resolved.
Individuals who do not meet the above four criteria should not be listed as authors but should be acknowledged. All authors are expected to make meaningful contributions to this work. The publisher strictly prohibits false authorships, including those obtained through purchase, and only recognizes genuine contributions. Authors should disclose whether artificial intelligence (AI)-assisted technologies were used in the preparation of their manuscripts and how they used them. Authors should also report the use of AI for writing assistance in the Acknowledgment section. AI tools should not be used in sections that rely on human intellectual analysis, such as data interpretation and conclusion summarization.
A corresponding author should be marked with "*", and the maximum of corresponding authors is two. A corresponding author serves as a representative of the authors and is responsible for contacting editors and reviewers, e.g., submitting manuscripts, responding to reviews, accepting queries, proofreading galleys, making corrections, etc.
Changes to Authorship
Authorship changes (addition, deletion, or rearrangement of author names) should be made before the acceptance of the manuscript. Confirmation from all authors (including existing authors and author(s) to be added and/or removed) should be provided to the editorial office of the journal, together with the reason for such changes. Changes can be made after the approval of the journal. The publisher will deal with any changes or dispute over authorship following the COPE flowcharts of authorship and contributorship.
Authors are required to declare any potential conflicts of interest (financial or non-financial). Any agreements with study sponsors (for-profit or non-profit), such as those that interfere with the authors' access to the study's data or with the authors' ability to analyze or interpret the data and to publish manuscripts independently according to their own decision, should be avoided by authors at all costs.
APACSCI also requires reviewers and editors to declare any (potential) non-financial conflicts of interest and declare any unpaid roles or relations that may influence the decision on the manuscript's publication. These include, but are not limited to, unpaid roles in a governmental or non-governmental organization, unpaid roles in an advocacy or lobbying organization, and unpaid advisory positions in a commercial organization.
In addition, reviewers and editors must disclose any association that poses a conflict of interest in connection with the manuscript. Examples are personal or work-related relationships with one of the authors or the reviewer is on the authors' avoidance list.
Following COPE guidelines, APACSCI will not accept any misconduct behaviors that may mislead researchers.
Plagiarism
Plagiarism is not acceptable. Using the content from one's own previously published articles without proper citation is also considered plagiarism. APACSCI adopts Crossref Similarity Check (powered by iThenticate) for checking the originality of submissions. Manuscripts with a high similarity index may be rejected.
Fabrication and falsification
Fabrication and falsification of data or images will mislead researchers. APACSCI strongly opposes such practices and will reject suspicious submissions.
Duplicate submission
Duplicate submission of a manuscript that has been published or submitted to other journals at the same time will not be considered.
Manipulation
Peer review manipulation is expressly forbidden. In particular, peer review manipulation by editors involves ethical issues, and when detected or complained about, editors are dealt with seriously and are subject to dismissal.
Eliminate excessive manipulative citation included in the peer review process by reviewers. Reviewers are encouraged to suggest that authors add references that are necessary and constructive to the research. Reviewers' own articles that do not contribute to the scholarly content of the author's work must not be oversold for the sole purpose of inflating the number of citations to the reviewer's own article.
Authors are prohibited from over-citing their own previously published articles. The journal's editorial board will determine self-citation thresholds, which authors must strictly adhere to in order to eliminate any suspicion of citation manipulation.
Editors will be involved in the journal management process to detect citation manipulations from authors or reviewers.
As behaviors above are illegal academic and very unethical, the Publisher will deal with it seriously. If any misconduct action is verified, authors and their institutions will be informed, and all the journals of the Publisher will not receive any new submission from these authors and their institutions in three years. If the allegations are disputable, their institutes are responsible to cooperate with the journal in investigating allegations.
If there are any suspicious allegations of the processing of articles especially the peer review process, referring to For Reviewers, the Editor-in-Chief will receive the complaint, and an investigation group will be formed to investigate the entire process, including the reviewers, editors, and staff who are involved. The journal will follow the procedures described in COPE and Publishing Ethics for handling allegations of misconduct.
The language of all manuscripts must be English (either British or American) and non-English words should be used sparingly. Poor English may lead to article rejection. Authors are encouraged to seek language polishing by a native English speaker or a professional editing service.
Correction
Authors are responsible for approving the final version of their manuscript and they should avoid any errors prior to publishing. In the case of errors that occur in a published article and have no influence on research results, APACSCI will issue a correction/erratum.
Authors, readers, and editors are encouraged to report any errors found in published papers. Please contact the editorial office of the particular journal.
Retraction
Based on COPE guidelines, the following conditions can lead to the retraction of a published article:
Unreliable findings
Plagiarism
Published elsewhere without proper attribution to previous sources, disclosure to the editor, permission to republish, or justification
Containing material or data without the authorization for use
Infringement of copyright, violation of privacy, or other legal issues
Unethical research
Dubious peer review processes
Failing to disclose a major competing interest
If any of the above misconduct proved to be true, a retraction notice will be issued with the reason, while the PDF of the retracted article will be watermarked with "Retracted". The journal editors will inform the authors of the retraction.
Paid Article Processing Charges will not be refunded to the authors if retraction occurs.
Withdrawal
Although not encouraged, authors can initiate the withdrawal of their submission before and during the peer review process by providing the reason. However, authors should note that a penalty fee of US$200 will be imposed for the withdrawal of a submission undergoing the peer review process due to the spent efforts on the evaluation of the manuscript by the editors and reviewers. Upon the approval of submission withdrawal, the submission will be removed from the journal's operation system, and the authors be informed.
Accepted articles and articles in press may also be withdrawn due to infringements of professional ethical codes (similar reasons to those for retraction).
APACSCI allows authors to post preprints of the manuscript of their original research articles (limited to only this type of article) on community preprint servers, such as arXiv, bioRxiv, and PeerJ Preprint, prior to or simultaneous with their manuscript submission to APACSCI journals. Authors retain the copyright of the manuscript posted on a preprint server.
Authors should inform the editors of the preprint version of their submitted manuscript in a cover letter, as well as provide any associated accession numbers or DOIs. Revised versions per the result of the peer review process and accepted versions for publication should not be posted on a preprint server.
Upon publication of the article, APACSCI encourages authors to link the article in the preprint server to the journal site, so as to guide readers to access and refer to the final version of the article.
Authors should read the "Author Guidelines" before making a submission, and make sure that the manuscripts were written in accordance to the style and specifications of the journal's policy.
All manuscripts submitted to Cardiac and Cardiovascular Research are subject to rigorous peer review. Prior to peer review process, the manuscripts will be screened for acceptable English language, novelty and relevance to the Focus and Scope of the journal.
Any manuscripts submitted to Cardiac and Cardiovascular Researchwill be treated as confidential materials. The manuscripts will not be disclosed to anyone except individuals such as editorial staff, reviewers and editors who participate in the initial screening, review, processing and preparation of the manuscript for publication (if accepted).
A manuscript would not be accepted if it has been published or is currently under consideration for publication in any other journals. The authors are required to notify the editorial team if the findings and data in their submissions have been presented in conferences.
The opinions, statements, methods, results, and data in APACSCI's published articles are those of the authors and do not reflect the opinions of APACSCI and its editors. APACSCI disclaims responsibility for any injury to people or property resulting from any ideas, methods, or products referred to in the articles or advertisements.
Authors contributing to APACSCI journals retain the copyright.
All articles published by Cardiac and Cardiovascular Researchare licensed under the Creative Commons International Licenses. Without any explicit request from the corresponding author during the submission stage, a paper will be published under the Creative Commons Attribution 4.0 International License (CC BY 4.0) by default. Authors who would like to publish their work under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0), they should express their request during the submission stage. Please include the statement below in the "Comments for the Editor column" on the submission page:
The contributors or authors for this submission entitled "[MANUSCRIPT TITLE]", i.e. [NAMES of ALL AUTHORS], have given their consents to alter the Creative Commons License to *CC BY-NC 4.0* under which this submission will be published in Cardiac and Cardiovascular Research.
It is the responsibility of authors to obtain permission to reuse material previously published under a more restrictive license from the copyright holder before the submission stage. These may include figures, tables, and schemes.
The publisher requests that this journal only consider advertising applications that are relevant to the contents of the journal, if available.
The publisher (APACSCI) reserves the right to accept or refuse advertising. The Journal Editorial Office will evaluate whether to accept the request.
Advertisements must comply with relevant rules and laws in the country where they will appear.
Advertisements should be legible and advertisers identifiable. Sponsors may not arrange or influence editorial decisions including any content in the journal.
Advertisements must not be misleading or deceptive. Advertising content must not contain indecent, offensive, or sensitive information (such as politics, ethnicity, gender, religion, etc.).
APACSCI disclaims responsibility for any damages resulting from advertisements in its journals. The publisher or journal does not accept advertisements for products or services known to be harmful to health/science or contrary to academic principles.
Unless the advertiser requests differently, all advertisements posted by the publisher will be displayed at random. Special requests need to be addressed to the publisher, who will make a final decision on a case-by-case basis within 7 working days.
Advertising is independent, with journal web features and academic content free from all advertising and product interference.
Once an advertisement is posted online, it will be removed from the journal's website at any time if the Editor-in-Chief or publisher requests that it be removed.
APACSCI's publishing model is open access. Open access enables readers to freely access and download articles immediately after publication online. APACSCI charges authors article processing charges (APCs) so as to cover operation costs, such as those arising from the evaluation and production processes. APCs should be paid upon the acceptance of articles and ahead of publication.
APCs of Cardiac and Cardiovascular Researchare USD $300.
Waiver and Discount Policy
APACSCI believes there should be no barriers to the dissemination of knowledge, and thus APACSCI offers APC waivers and discounts to authors from low-income countries and authors with special circumstances. Authors should write to the editorial office of the specific journal to apply for waivers and discounts. The decision to approve such applications is made by the editorial office on a case-by-case basis.
All the articles published online will be archived by Portico for long-term digital preservation.
Authors are encouraged to self-archive the final version of their published articles into institutional repositories (such as those listed in the Directory of Open Access Repositories).
Authors are also encouraged to use the final PDF version published on the website ofCardiac and Cardiovascular Research.
Cardiac and Cardiovascular Research (CCR) has been indexed by several world-class abstracting/indexing databases:
Google Scholar
Scilit
EuroPub
We aim to be included in the first-class academic databases in the world, such as WoS, Scopus, Inspec, and EI.
The Section Collection program has been driven by Asia Pacific Academy of Science Pte. Ltd. for a new chance to run an open access journal. This program aims to collect multidisciplinary topics, and concentrate authors from diverse research fields to focus on a special theme. It is great attempt to develop new ideas and applications. Section editorial team is composed of many scientists whose research fields covering various interests. They all supervise the implementation of the program, and the editorial process must comply with editorial policies of each journal.
A Section Collection is usually launched by an expert with great trust among peers and invited by the Editorial Office, or scholars could apply a section collection. Section Editors are representatives focusing on a theme from multidisciplinary topics. They have different research background, and gather to initiate new ideas and collaborations. Great responsibilities of Section Editors include:
Preparing the title, summary, keywords, submission deadline, etc.
Preparing a potential contributors' list.
Suspecting and contributing to the editorial progress, including but not limited to the initial screening, and the peer-reviewed process.
Workflow of Section Collections
Manuscripts should be submitted to Open Journal Systems (OJS) and go through a double-blinded peer-reviewed process (refer to Peer Review Policy).
For authors:
Researchers using an Artificial Intelligence Generated Content (AIGC) tool/service to directly generate the manuscript text must provide clear disclosures and statements, otherwise it will be considered academic misconduct. The journal allows the use of an AIGC tool/service for text embellishment and automatic sorting of references, but does not recommend the use of the AIGC tool/service in the thinking and concluding sessions of human involvement such as data analysis and interpretation, opinion hypothesis and conclusions, and the AIGC tool/service cannot fulfill the role of a textual author. If any part of the manuscript was written using an AIGC tool/service, it must be described openly, transparently, and in detail in the Methods or Acknowledgments section, for example:
"In the preparation of this work, the authors used the [name of the specific AIGC tool/service] to [purpose of use: e.g., literature research/text embellishment, etc.]. After using this tool/service, the authors reviewed and edited the content as needed, and take full responsibility for the content of the publication."
For Reviewers:
Reviewers are required to disclose whether any artificial intelligence (AI) tools were utilized in the preparation of their review reports. This disclosure should be clearly indicated as a note within the reports themselves.
Cardiac and Cardiovascular Researchadopts and follows the rules of International System of Units (SI) for physical quantities and units of measurement. For example:
Quantities including time, length, mass, electric current, etc., should be written as s (second), m (metre), kg (kilogram), A (ampere) after metric numbers.
Adopt unified format for the same unit of measurement.
According to the data and reproducibility of COPE, APACSCI encourages authors to share associated data, code, and materials, register clinical trials, and use standardized guidelines to achieve greater transparency, replicability, and trust in scientific findings. Thus, authors are encouraged to deposit datasets in a data repository; the premise is that this data is not suitable for submission as online supplementary files. Authors who have deposited raw data in community database repositories are encouraged to include a data availability statement in their manuscript. The statement should provide information about the availability of the research data and any limitations or conditions associated with accessing the data, except for reasonable controls related to human privacy or biosecurity. Reusing scientific data can offer great potential for further scientific and economic development.
Data sharing
For data shared, the FAIR Data Principles should be followed, which guides that (meta)data are assigned a globally unique and eternally persistent identifier. Authors should cite the correct sources. Collaborative practices should be implemented across journals and institutions to monitor and ensure the scientific validity and credibility of overall research practices. Authors are encouraged to prioritize the use of original data from their study and provide supporting data such as accessible data sources as early as possible.
Regarding data involving confidentiality/privacy/personal privacy, etc., authors are advised to do their best to hide identifiable sensitive information and to share data in strict accordance with mandatory guidelines for the discipline.
According to the guidelines of COPE regarding unpublished data, the journal will address concerns to the data provider regarding the scientific rigor of an unpublished dataset. The journal will contact the corresponding author, and request comments on the concerns, supporting documentation as needed, and information about any other affected content. Following the guidelines regarding published data, if there is a manuscript associated with a published dataset whose scientific rigor is in doubt, the journal will contact any implicated journals that have published results from the suspicious dataset, summarizing the issue and actions taken to date. Authors must respond with a satisfactory update. If the issues are major or impact the conclusions of the manuscript, the author(s) should withdraw the manuscript or the journal will reject the submission.
Data citation
Authors are encouraged to cite any datasets deposited in external repositories mentioned in their manuscript in the references. For previously published datasets, authors should cite both the published research article and the source of the dataset itself. Journal editorial staff will check and enforce proper data citation before publication.
Data citations should include the minimum information recommended by DataCite:
1) Author(s)
2) Year of publication/release
3) Title
4) Publisher/repository or archive name
5) Persistent identifier (e.g., DOI)
Data repository
Authors are encouraged to deposit their datasets in the relevant community dataset repository, or a general dataset repository (including any generalist data repository provided by a university, funder or institution for its affiliated researchers) that aligns with the specifications and requirements of their discipline could be selected. The publisher recommends that authors select a repository with a DOI (Digital Object Identifier) to ensure that the referenced dataset can be linked to consistently.
Authors could explore online resources for lists of registered data repositories through FAIRsharing.org and re3data.org.
Here are some examples of generalized dataset repositories:
The Journal complies with the standards of WHO ICPRP and ICMJE regarding to clinical trial registry. According to the WHO ICPRP and ICMJE, a clinical trial is any research study that prospectively assigns human participants or groups of humans to one or more health-related interventions to evaluate the effects on health outcomes. Clinical trials may also be referred to as interventional trials. Interventions include but are not restricted to drugs, cells and other biological products, surgical procedures, radiologic procedures, devices, behavioural treatments, process-of-care changes, preventive care, etc. This definition includes Phase I to Phase IV trials.
The Journal requires that all research protocols involving a first clinical trial be registered in a public clinical trial registry (except those that have already been published). WHO regards trial registration as the publication of aninternationally-agreed set of information about the design, conduct and administration of clinical trials. This requirement is not only conducive to increasing the transparency of clinical trial information and reducing publication bias, but also conducive to guaranteeing the quality of clinical trials, increasing the standardization of the trial process and the credibility of the test results.
Authors whose manuscript involve clinical trials, should demonstrate the trial registry information in a cover letter, such as the name of trial registry, and the unique ID number assigned by the Primary Registry to this trial. Meanwhile, authors also should mention the trial registry information at the "Materials and Methods" section with appropriate references. Secondary data analyses of primary (parent) clinical trials should not be registered as separate clinical trials, but instead should reference the trial registration number of the primary trial.
Before submitting to the journal, authors should read through the author guidelines for preparing their manuscript. Starting in 2024, a new layout style will be applied, so please download the new manuscript template.
Manuscript Format
The manuscript should be in MS Word format. The language of all manuscripts must be English (either British or American) and non-English words should be used sparingly. Poor English may lead to article rejection. Authors are encouraged to seek language polishing by a native English speaker or a professional editing service.
Article Types
Please refer to the Section Policy for choosing an appropriate type.
Cover Letter
Authors should attach a cover letter together with the article text. A cover letter should encompass a declaration of originality, affirm compliance with the journal's editorial policies, and also contain a brief explanation of the significance of their work and the intention of doing the work. If the work involves the human and animal research, authors should provide the Informed Consent Statement or Ethical Approval ID attached with cover letter. The cover letter is confidential and will be read only by the editors. It will not be seen by the reviewers.
Article Title
Titles should be no more than 50 words, with significant and attractive information for readers. Titles should not include uncommon jargons, abbreviations, and punctuation.
List of Authors
The list of authors should be arranged based on the level of their contribution, with the major contributor listed first. Corresponding authors should be marked with an asterisk (*). Affiliation information should be provided with the following elements: department, institution, city, postal code (if available), and country. The email address of at least one corresponding author must be provided. All authors must approve the final version of the manuscript and agree with the submission. For more information about authorship, please refer to our Authorship Policy.
Abstract and Keywords
Depending on the article type, an abstract should be provided, which gives a concise summary of the article. It is usually a single paragraph of about 200–250 words maximum. Between 5–8 keywords should be included. Words and phrases in article titles should be avoided as keywords.
Text
The text of manuscripts should be in MS Word format. Original research articles should include the Introduction, Materials and Methods, Results, Discussion, and Conclusion (optional) sections.
Section Headings
Headings are used to indicate the hierarchy of the sections of the text. No more than three levels of headings should be employed. The first level of heading should be numbered as 1., 2., 3., 4. in boldface. Likewise, the second and third levels of headings should also be in boldface, for example, 1.1., 1.2., 1.1.1., 1.1.2.
Introduction
The introduction should provide a background that gives the broad readership an overall outlook on the field and the research performed. It pinpoints a problem and states the significance of the study. The introduction can conclude with a brief statement on the aim of the work and a comment about whether that aim was achieved.
Materials and Methods
This section provides the general experimental design and methodologies used. The aim is to provide enough details for other investigators to fully replicate the experiments. It is also to facilitate a better understanding of the results obtained.
Results
This section can be divided into subheadings. This section focuses on the results of the experiments performed.
Discussion
This section should provide the significance of the results and identify the impact of the research in a broader context. It should not be redundant or similar to the content of the Results section.
Conclusion (Optional)
The conclusion section can only be used for interpretation, and not be used to summarize information already presented in the text or abstract.
Figures and Tables
Figures (photographs, images, graphs, charts, and schematic diagrams) and tables should be referred to within the main text and numbered consecutively as Figure 1, Figure 2, Table 1, Table 2, etc. They should be placed as close as possible to where they are first cited and center-aligned. Both figure captions and table captions should be center-aligned, with figure captions set underneath the figures and table captions above the tables. When captions are longer than one line, they should be left-aligned.
Figures can contain multiple panels. They should be numbered by Latin letters with parentheses, e.g., (a), (b), (c), or (A), (B), (C), placed below the image or within the image.
Tables should be in MS Word/Excel table format. Tables containing too much information can be provided as supplementary material.
In the main text, all figures and tables should be cited, e.g., "Table 1 indicates…", "Figures 1 and 2 shows…", and "Figure 1a,b shows…".
Lists and Equations
Both bulleted lists and numbered lists are acceptable (refer to the template). Equations should be center-aligned and equation numbers should be right-aligned. If cited in the text, equations should be labeled with numbers in parentheses, e.g., Equation (1).
In-Text Citations
All bibliographical references that make an important contribution to the article should be numbered according to the appearance order. When cited in the text, the number should be placed in square brackets, for example:
Negotiation research spans many disciplines [3,4].
This effect has been widely studied [1–5,7].
Appendix (Optional)
An appendix provides information supplementary to an article and is included at the end of the article after the References section and it should start on a new page. For one appendix, it is designated as "Appendix"; for more than one appendix, they are designated "Appendix A", "Appendix B", etc.
An appendix should be cited in the main text. Tables, figures, and equations should be started with the prefix A (i.e., Figure A1, Figure A2, Table A1, etc.).
Back Matter
The sequence of back matter elements in an article is listed below. There is no numeral label for back matter headings. Some of these elements are optional.
Supplementary Materials (Optional)
The Supplementary Materials section provides a short description of the supplementary materials. One or more individual supplementary files are allowed and should be submitted in Step 4 during submission. These materials are relevant to the manuscript but remain non-essential to readers' understanding of the article's main content. Please ensure the names of such files contain "suppl. info". Videos may be included in this section.
Author Contributions
For original research articles, this section is required, except when there is only one author for the article. The contribution of each co‐author should be reported in this section.
The following statements should be used "Conceptualization, XX and YY; methodology, XX; software, XX; validation, XX, YY and ZZ; formal analysis, XX; investigation, XX; resources, XX; data curation, XX; writing—original draft preparation, XX; writing—review and editing, XX; visualization, XX; supervision, XX; project administration, XX; funding acquisition, YY. All authors have read and agreed to the published version of the manuscript."
Funding (Optional)
Authors can acknowledge financial support in this section, which is NOT mandatory. If authors provide a funding statement, it should be in the same style as the template.
For example:
"This research was funded by [name of funder] grant number [xxx]" and "The APC was funded by [XXX]". Please check carefully that the details given are accurate and that the standard spelling of the funding agency's name in https://search.crossref.org/funding is used, as any errors may affect the authors' future funding.
Acknowledgments (Optional)
Authors can acknowledge any support and contribution that cannot be included in the Author Contributions and Funding sections. This section is NOT mandatory.
Conflict of Interest
According to our Conflict of Interest Policy, all authors are required to declare all activities that have the potential to be deemed as a source of competing interest in relation to their submitted manuscript. Examples of such activities include personal or work-related relationships and events. Authors who have nothing to declare should add "No conflict of interest was reported by all authors" or "The authors declare no conflict of interest" in this section.
References
This section is compulsory and should be placed at the end of the manuscript. Footnotes or endnotes should not replace a reference list. The list of references should only include works that are cited in the text and that have been published or accepted for publication. Personal communications should be excluded from this section.
The format of author names should be "Last-Name Initial", e.g., David Smith should be written as Smith D.
Journal
Journals in English:
Author AA, Author BB, Author CC, et al. Title of the article. Journal Name. Year, Volume(Issue) (if available): Firstpage–Lastpage. doi (if available)
Journals in languages other than English:
Author AA, Author BB, Author CC, et al. English title of the article (original language). Journal Name. Year, Volume(Issue) (if available): Firstpage–Lastpage. doi (if available)
Book
A book without editors:
Author AA, Author BB. Chapter (optional). Title of the Book, Edition (if available). Publisher; Year. pp. Page range (optional).
A book with editors:
Author AA, Author BB. Title of the contribution. In: Editor CC, Editor DD (editors). Title of the Book, Edition (if available). Publisher; Year. Volume (optional), pp. Page range (optional).
For a translated book, the translators' names should be placed after the editors' names: "Translator AA (translator)" or "Translator AA, Translator BB (translators)".
If the editors and translators are the same, the format should be as follows:
Author AA, Author BB. Title of the contribution. In: Editor CC, Editor DD (editors and translators). Title of the Book, Edition (if available). Publisher; Year. Volume (optional), pp. Page range (optional).
Conference
Full citations of published abstracts (proceedings):
In most cases, proceedings will be simply called "Proceedings of the Name of the Conference (full name)" without a book title. In this case, please only add the conference name in the proceedings' title and keep that in regular font (i.e., do not italicize):
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Abstract
We investigated the association between cardiac factors, spirometry, and exercise testing in patients with tetralogy of Fallot (TOF). Clinical data from patients with TOF performing a cardiopulmonary exercise test (CPET) was collected retrospectively over a 10-year period. 122 patients with TOF were identified, 52 excluded for incomplete exercise, spirometry, or cardiac data for 70 total patients included in the study. There was a male predominance 39 (56%), a mean age of 25 ± 12 years, with 28 (40%) < 18 years of age. The mean number of cardiac surgeries was 2.1 ± 1.2. Most, 46 (69%) had moderate to severe pulmonary valve insufficiency (PI) and 34 (51%) had moderate to severe right ventricular (RV) dilation. Mean forced vital capacity (FVC) was low at 81.8% predicted, and 32 (46%) with low FVC (< 80% predicted). Overall peak VO 2 /kg was low with a mean of 58.2 ± 13.2 % predicted. Using multiple regression analysis, a higher number of cardiac surgeries was an independent predictor of lower FVC ( p = 0.01). Lower FVC was itself an independent predictor of lower peak VO 2 /kg and O 2 pulse ( p < 0.05). Moderate or severe RV systolic dysfunction was an independent predictor of stroke volume response ( p = 0.03). Higher body mass index (BMI) was an independent predictor of all exercise measures being worse ( p < 0.05). Low FVC and reduced exercise capacity were common in our population of TOF patients. Low FVC was predictive of low exercise capacity while, of the cardiac measures only RV systolic dysfunction was significant and predictive of stroke volume response. Spirometry may be a valuable screening tool in evaluation of TOF patients.
Received: 30 October 2023; Accepted: 4 January 2024; Available online: 12 February 2024; Issue release: 30 June 2024
Abstract
Endocarditis is a rare and potentially fatal infection of the endocardium. Bartonella endocarditis is an emerging disease that causes serious complications and high rates of mortality. Due to the fastidious nature of Bartonella species and their high degrees of antibiotic susceptibility, cultures of clinical samples most often remain sterile. The best specimens for polymerase chain reaction amplification are seldom available. The diagnosis of Bartonella infections relies mainly on serological methods. We report the case of a 58-year-old woman with dyslipidemia who presented with nocturnal fever, polyarthralgia, sweats and weight loss. The diagnosis of Bartonella endocarditis was confirmed by an indirect immunofluorescence assay. Medical treatment alone was efficient for our patient without any surgery.
Received: 23 April 2024; Accepted: 16 May 2024; Available online: 31 May 2024; Issue release: 30 June 2024
Abstract
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide, accounting for a significant proportion of healthcare costs. It is a major public health concern, and early detection and prevention are critical for reducing its burden. Several risk factors for CVD have been identified, including age, sex, genetics, hypertension, diabetes, smoking, and physical inactivity. Despite the identification of several risk factors, there is still a lack of understanding of the underlying mechanisms that contribute to CVD development. This study aimed to investigate the potential predictors of CVD and identify novel biomarkers that could be used for early detection and prevention. The study explored pre-processing strategies, including Synthetic Minority Oversampling Technique (SMOTE), Z-Score Normalization, and Adaptive Synthetic Sampling (ADASYN), to address class imbalance and enhance model performance. The dataset consisted of medical images labeled with different cardiovascular diseases. By integrating the strengths of Support Vector Machines (SVM) classification and Linear Discriminant Analysis (LDA), Principal Component Analysis (PCA), and PCA with ReliefF feature retrieval methods, the study investigated various feature extraction approaches for classifying cardiovascular diseases.
Received: 15 April 2024; Accepted: 20 May 2024; Available online: 2 June 2024; Issue release: 30 June 2024
Abstract
Among the risk factors for dry mouth, or xerostomia, are both estrogen deficiency in women during menopause and the use of medications with xerogenic properties. Until now, it has not been clearly determined, whether dryness in the oral cavity in women during menopause is only associated with subjective sensations or is accompanied by qualitative and quantitative changes in mixed saliva. To determine the frequency and nature of xerostomia syndrome in women during menopause with high and extremely high risk of cardiovascular diseases. The study involved 35 patients (with subjective sensations of dryness in the oral cavity) and 20 apparently healthy women. All study participants were questioned for any dental complaints, and the quantitative indicators of the oral fluid were assessed. An individualized oral hygiene complex and a moisturizing gel were prescribed as correction of the subjective signs of xerostomia. The follow-up visit was carried out after 1 month. The patients in natural menopause felt slight subjective manifestations of dry mouth confirmed by objective decrease in salivary secretion; whereas in most cases subjective dryness in the oral cavity is accompanied by normal secretion. The prescribed complex for correction of dental complaints ensures decrease in the subjective signs of dryness, decrease in taste distortion and halitosis.
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Editor-in-Chief
Prof. Prakash Deedwania
University of California,
San Francisco, United States
Indexing and Archiving
News & Announcements
2024-09-08
September 16: International Day of Interventional Cardiology
WInternational Interventional Cardiology Day aims to raise public awareness of cardiovascular disease and surgery, related complications, and prevention and care.