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Stimulating effect on behavioral and cognitive functions of mice at silver citrate exposure
Vol 39, Issue 4, 2025
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Abstract
Influence of long-term daily oral exposure of C57BL/6 male mice during up to 180 days to 50 μg/day/animal of silver citrate on their cognitive and behavioral functions was studied in the present work. The behavioral and cognitive functions’ change can be expressed as the three-staged process, such as (1) anxiety increase, (2) susceptibility (sensitivity) increase, (3) tendency to improve long-term contextual memory at the background of decreased anxiety and locomotion increase. Thus, the influence of silver citrate on behavioral and cognitive functions of mice is complex, time-dependent alterations. The observed effect of stimulation of behavioral and cognitive functions at silver citrate exposure at the final stage can be applied in Medicine for treatment of neurodegenerative diseases as well symptoms of mental illness. Silver citrate may potentially replace silver nanoparticles, which are well-known from scientific literature to be toxic.
Keywords
References
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Supporting Agencies
Russian Science Foundation
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Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy