This study investigates the effectiveness of coping strategies, computer sciences, and psychological interventions in managing depression and anxiety among leukemia patients. Given the high prevalence of psychological distress in this population, the research employed a combination of randomized controlled trials (RCTs), systematic literature reviews, and qualitative analyses through patient interviews and clinical observations. The experimental tests included interventions such as Cognitive Behavioral Therapy (CBT), mindfulness-based stress reduction programs, supportive psychotherapy, and structured coping strategy workshops. Results demonstrated a significant reduction in depression and anxiety symptoms among patients receiving these interventions compared to those under standard care. Improvements were observed in emotional regulation, coping skills, quality of life, and treatment adherence, with CBT and mindfulness interventions yielding the most pronounced effects. The study contributes to the growing body of evidence supporting the integration of psychological care into standard leukemia treatment protocols. It emphasizes the critical role of adaptive coping mechanisms and psychological support in enhancing both mental health and clinical outcomes, advocating for comprehensive, interdisciplinary approaches.