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Deciphering Tetraspanins: Dual Roles in Cancer Progression and Therapeutic Implications
Vol 38, Issue 6, 2024
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Abstract
Tetraspanins, characterized by their four transmembrane domains, function as versatile platforms for interactions with a wide range of molecules. Recent research has increasingly focused on the utility of tetraspanins as potential prognostic markers and indicators of metastatic likelihood, varying according to the type of cancer. This review comprehensively examines the multifaceted functions of tetraspanins, highlighting their dual roles as enhancers and inhibitors in cancer development. Furthermore, it provides a detailed exploration of the signaling pathways and interactions associated with tetraspanins that could significantly impact the course and treatment of cancer.
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Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy