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Copper and Gastric Cancer: Looking Back from the Perspective of Cuproptosis
Vol 38, Issue 6, 2024
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Abstract
Copper (Cu), an essential trace element, plays a crucial role in various physiological processes within the human body. Recently, cuproptosis, a novel form of cell death induced by copper overload, has been identified. Despite numerous studies investigating the association between copper and gastric cancer (GC), a comprehensive review of the existing literature on this topic is notably lacking. This review provides a retrospective analysis of the correlation between copper and gastric cancer, outlines the aberrant copper metabolism in gastric cancer and its potential mechanisms, and synthesizes current bioinformatics research on cuproptosis in gastric cancer. Furthermore, the review delves into copper-related synthetic materials and drugs that have been pivotal in the diagnosis and treatment of gastric cancer. We have emphasized that the association between copper and gastric cancer has not been fully investigated, indicating the possibility of discovering copper-related synthetic materials, chelating agents, and complexing agents as potential therapeutic approaches for gastric cancer.
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Copyright (c) 2024 Shunyao Zhang, Jiayan Pan, Lu Gan, Xiaoyun Ding
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Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy