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The Diagnostic and Prognostic Potentials of TSPANs in Cancer: A Comprehensive Review
Vol 38, Issue 1, 2024
Abstract
Tetraspanins are four transmembrane proteins that serve as a platform for interacting with a wide range of different molecules. It plays a crucial role in oncogenesis as well as in the metastasis in various cancer types. Numerous studies have investigated the use of various members of the tetraspanin family as prognostic markers and predictors of metastatic potential according to specific cancer types. This manuscript provides an overview of these advances, and their limitations, and suggests insights into future research areas for their clinical applications. Furthermore, the potential value of tetraspanin as a tumor-associated antigenic target will also be discussed in this review.
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Copyright (c) 2024 Kun Zhao, Yijun Tian, Li Yang, Liping Wang
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Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy