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The Role of the Notch Signaling Pathway in Neurogenesis, Neurodifferentiation and Neurodegenerative Diseases: From Fundamental Knowledge to the Search for Therapeutical Approaches
Vol 37, Issue 12, 2023
Abstract
The Notch signaling pathway plays a crucial role in embryonic development as well as in maintaining tissue homeostasis throughout the lifespan of an adult organism. The involvement of this signaling pathway in the development of certain neurodegenerative diseases and other nervous system disorders is known, yet a comprehensive therapy related to the Notch signaling pathway has not been developed. This underscores the importance of further investigating the molecular mechanisms of the Notch signaling pathway. This review explores the molecular mechanisms by which the Notch signaling pathway participates in neurogenesis and neural differentiation. Finally, we discuss the role of Notch in neurodegenerative pathologies and possible therapeutic approaches.
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Copyright (c) 2023 Anna Malashicheva, Arina Zakharova, Nataliia Katolikova
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Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy