Therapeutic Effect of Partial Splenic Embolization on Liver Cirrhosis with Hypersplenism and Its Effect on Portal Blood Flow and T Lymphocyte Function

Yifei Wang; Lizhen Liu; Peng Xu; Runsheng Guo; Shanjuan Wang

doi:10.23812/j.biol.regul.homeost.agents.20233711.562

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Asia Pacific Academy of Science Pte. Ltd. (APACSCI) specializes in international journal publishing. APACSCI adopts the open access publishing model and provides an important communication bridge for academic groups whose interest fields include engineering, technology, medicine, computer, mathematics, agriculture and forestry, and environment.

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Macrophages in the pathogenesis of psoriasis and anti-psoriatic nanotherapies

Psoriasis is a common, chronic, and inflammatory skin disease. Macrophages account for about 61.3% of the inflammatory cells infiltrating psoriatic lesions. Modulating macrophage polarization, inhibiting their infiltration, and targeting the secretion of inflammatory factors and associated inflammatory pathways by these cells can alleviate psoriasis symptoms and inflammation. Moreover, nanomaterials as novel drug carriers, offer unique advantages such as large surface area, easy modification, high biocompatibility, good biodegradability, enhanced systemic adsorption, etc. Nanomaterials have great potential for efficient drug delivery and release, as well as improving therapeutic efficacy while reducing adverse effects. By systematically addressing the role of macrophages in psoriasis pathogenesis and the potential of nanomaterials in treating psoriasis through modulating macrophages, this review enhances our understanding of the disease mechanism and holds promise for novel therapeutic breakthroughs and advancements in the future treatment of psoriasis.

Therapeutic Effect of Partial Splenic Embolization on Liver Cirrhosis with Hypersplenism and Its Effect on Portal Blood Flow and T Lymphocyte Function

Yifei Wang, Lizhen Liu, Peng Xu, Runsheng Guo, Shanjuan Wang

Article ID: 7618
Vol 37, Issue 11, 2023

DOI: https://doi.org/10.23812/j.biol.regul.homeost.agents.20233711.562

Received: 9 December 2023; Accepted: 9 December 2023; Available online: 9 December 2023; Issue release: 9 December 2023

Abstract

Objective: This study aims to investigate the effect of partial splenic embolization (PSE) in the treatment of liver cirrhosis with hypersplenism and its influence on portal vein blood flow and T lymphocyte levels. Methods: Ninety-four liver cirrhosis patients with hypersplenism admitted to Jiading District Central Hospital from February 2018 to June 2021 were selected and randomly divided into two groups, with 47 cases in each group. The patients in Group A accepted PSE treatment, while patients in Group B accepted traditional splenectomy. Routine blood indices, portal vein hemodynamic indices, liver perfusion level, peripheral blood T lymphocytes and surgical complications were compared between the two groups at different time before and after the operation. Results: The levels of red blood cell, white blood cell, and platelet in Group A and Group B were considerably higher than those before the operation at 1 month and 3 months after the operation (p < 0.05). At 3 months after the operation, internal diameter of the portal vein, blood flow velocity of the portal vein, portal vein blood flow and portal vein pressure in Group A were lower than those in Group B (p < 0.05). At 3 months after the operation, hepatic artery perfusion (HAP) values in Group A were higher than those in Group B, and the portal vein perfusion (PVP) and total liver perfusion (TLP) values in Group A were lower than those in Group B (p < 0.05). Three months after the operation, the CD3+ and CD4+ values in Group A were higher than those in Group B (p < 0.05). The complication rate of Group A (8.5%) was lower than that of Group B (23.40%) (p < 0.05). Conclusion: The effect of PSE in treating liver cirrhosis with hypersplenism is better than that of traditional splenectomy. It has better effect on improving portal vein blood flow and liver perfusion, promoting the recovery of immune function and causing fewer complications.

Keywords

splenic artery embolization;liver cirrhosis;hypersplenism;portal blood flow parameters;T lymphocytes

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Medical Genetics, University of Torino Medical School, Italy

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Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy

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2025-02-01

Notice of Change in Publication Schedule

In addition to the first issue that has already been published by the original publisher, there will be four more issues released this year, with scheduled publication dates in March, June, September, and December respectively.

2025-01-21

Notice: Ownership Transfer of the Journal

Starting from Volume 39 Issue 2 (2025), the ownership of Journal of Biological Regulators and Homeostatic Agents (ISSN: 0393-974X (P); 1724-6083 (O)) will be transferred from Biolife Sas to Asia Pacific Academy of Science Pte. Ltd. As of 21 January 2025, authors should make submissions to the new journal system and follow the author guidelines. Asia Pacific Academy of Science Pte. Ltd. will take over the publication of manuscripts being processed.

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