The Association between DNA Methylation and Non-Alcoholic Fatty Liver Disease: A Systematic Review

Bahar Golastani; Parnian Poursafa; Motahar Heidari-Beni; Roya Kelishadi

doi:10.23812/j.biol.regul.homeost.agents.20233710.495

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Asia Pacific Academy of Science Pte. Ltd. (APACSCI) specializes in international journal publishing. APACSCI adopts the open access publishing model and provides an important communication bridge for academic groups whose interest fields include engineering, technology, medicine, computer, mathematics, agriculture and forestry, and environment.

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Macrophages in the pathogenesis of psoriasis and anti-psoriatic nanotherapies

Psoriasis is a common, chronic, and inflammatory skin disease. Macrophages account for about 61.3% of the inflammatory cells infiltrating psoriatic lesions. Modulating macrophage polarization, inhibiting their infiltration, and targeting the secretion of inflammatory factors and associated inflammatory pathways by these cells can alleviate psoriasis symptoms and inflammation. Moreover, nanomaterials as novel drug carriers, offer unique advantages such as large surface area, easy modification, high biocompatibility, good biodegradability, enhanced systemic adsorption, etc. Nanomaterials have great potential for efficient drug delivery and release, as well as improving therapeutic efficacy while reducing adverse effects. By systematically addressing the role of macrophages in psoriasis pathogenesis and the potential of nanomaterials in treating psoriasis through modulating macrophages, this review enhances our understanding of the disease mechanism and holds promise for novel therapeutic breakthroughs and advancements in the future treatment of psoriasis.

The Association between DNA Methylation and Non-Alcoholic Fatty Liver Disease: A Systematic Review

Bahar Golastani, Parnian Poursafa, Motahar Heidari-Beni, Roya Kelishadi

Article ID: 7591
Vol 37, Issue 10, 2023

DOI: https://doi.org/10.23812/j.biol.regul.homeost.agents.20233710.495

Received: 8 November 2023; Accepted: 8 November 2023; Available online: 8 November 2023; Issue release: 8 November 2023

Abstract

Background: Non-alcoholic fatty liver disease (NAFLD) is among the most common liver diseases. Epigenetic factors are involved in the development of NAFLD. However, studies have shown inconsistent results. This study aims to review the association between DNA methylation and NAFLD. Methods: A systematic search was conducted in the Medline database (PubMed), Web of Science, Scopus, and Google scholar until the end of October 2021. All observational studies including cross-sectional, case-control, cohort and English-language human studies that assessed the effects of DNA methylation on NAFLD were included. Results: Among 787 studies, 12 articles were included in the systematic review. Most studies showed that lower levels of DNA methylation in specific genes lead to NAFLD promotion. Among all the NAFLD-associated genes which were identified in the included studies, transforming acidic coiled-coil 2 (TACC2), STE20 Related Adaptor Beta (STRADB), Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) and Hepatocyte Nuclear Factor 1 Beta (HNF1B), appear more frequently compared to other genes. Conclusion: Results indicated a negative correlation between methylation status and NAFLD development. The role of DNA methylation can be considered as a risk factor for NAFLD.

Keywords

non-alcoholic fatty liver disease;epigenomics;DNA methylation

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Medical Genetics, University of Torino Medical School, Italy

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2025-02-01

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In addition to the first issue that has already been published by the original publisher, there will be four more issues released this year, with scheduled publication dates in March, June, September, and December respectively.

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