Unlocking the Secret to Combat Sepsis: The Revolutionary Approach of Modifying Gut Microbiome

Abstract

The microbiome in our digestive system plays a crucial role in maintaining a healthy balance and preventing diseases. Any imbalance in the microbiome, called dysbiosis, can increase the risk of sepsis and lead to a poor response to infection in the body. This review provides an overview of this topics extent, range, and nature by clarifying the gaps in current knowledge and planning for future works. Our research involved identifying clinical trials that administered biotics to adult patients with sepsis. We thoroughly reviewed the studies to determine if any harm was caused to the microbiome during sepsis treatment. In addition, we explored other literature to gain insights into the relationship between the microbiome and sepsis. Our findings indicate that biotic products have been used in treating septic patients in only three studies. The studies varied in terms of conditions, assessed outcomes, populations, and products administered. To ensure the patients well-being and avoid complications, treatment strategies for sepsis should prioritize maintaining a balanced microbiome and avoiding dysbiosis. Maintaining a healthy microbiome is not just about taking probiotic supplements. A deeper understanding of complex concepts like organ interaction and epigenetic modification can help understand the connection between the microbiome and sepsis, which could lead to new avenues of research. However, this is still a difficult task, and further clinical trials are needed to explore this area.