miR-3162-3p in Umbilical Cord Blood of Preterm Infants as a Diagnostic Biomarker for Neonatal Respiratory Distress Syndrome

Abstract

Background and Purpose: Neonatal respiratory distress syndrome (NRDS) commonly occurs in preterm infants with the involvement of MicroRNAs (miRNAs). This study evaluated the predictive significance of miR-3162-3p in NRDS onset and patients prognosis. Methods: Cord blood samples were collected from 100 preterm infants, including 50 NRDS neonates and 50 control neonates. The miR-3162-3p expression was detected by real-time reverse transcriptase-polymerase chain reaction (RT-qPCR), and the diagnostic value and predictive accuracy of miR-3162-3p were evaluated by receiver operating characteristic (ROC) analysis. The association between miR-3162-3p with NRDS onset and clinical outcomes was assessed by univariate and multivariate logistic regression analysis. Results: miR-3162-3p levels showed an up-trend in NRDS neonates and were associated with disease severity. miR-3162-3p had high diagnostic accuracy in NRDS and was related to NRDS onset. In addition, miR-3162-3p was highly expressed in NRDS neonates with poor prognosis and could high-accurately predict clinical outcomes. Conclusion: High miR-3162-3p in umbilical cord blood of NRDS neonates is correlated with NRDS onset and clinical outcomes.