Asia Pacific Academy of Science Pte. Ltd. (APACSCI) specializes in international journal publishing. APACSCI adopts the open access publishing model and provides an important communication bridge for academic groups whose interest fields include engineering, technology, medicine, computer, mathematics, agriculture and forestry, and environment.
Plasminogen Activator Inhibitor-1 as a Predictive Marker of Severity and Mortality in Sepsis: A Systematic Review and Meta-Analysis
Vol 37, Issue 6, 2023
Abstract
Background: Sepsis is an abnormal immune response to infection with unknown pathogenesis, seeing unacceptably mortality. Identifying biomarkers could help to diagnose sepsis and monitor its progress. Objective: We aimed to assess the correlation between plasminogen activator inhibitor-1 (PAI-1) levels, and the severity of sepsis and mortality. Methods: PubMed, Cochrane Library, and Excerpta Medica dataBASE (EMBASE) databases were searched based on “plasminogen activator inhibitor-1/PAI-1” and “sepsis”. Weighted mean difference (WMD) with its 95% confidence intervals (CIs) were computed on the eligible trials. Results: 11 trials encompassing 1606 sepsis patients were included. The PAI-1 levels were significantly higher in patients with sepsis-related death than in survivors (p < 0.001) and significantly higher in severe sepsis patients than in nonsevere patients (p = 0.001). Conclusions: PAI-1 could be considered a pivotal biomarker for the severity of sepsis and mortality.
Keywords
References
Supporting Agencies
Copyright (c) 2023 Xue Han, Yan Li, Jianrong Lu
This site is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy