Surveillance of Multi-Drug Resistant Bacterial Infections and Analysis of Changes in Colonization Trends from 2019 to 2021

Ye-ling Yang; Xiao-Hong He

doi:10.23812/j.biol.regul.homeost.agents.20233706.328

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Asia Pacific Academy of Science Pte. Ltd. (APACSCI) specializes in international journal publishing. APACSCI adopts the open access publishing model and provides an important communication bridge for academic groups whose interest fields include engineering, technology, medicine, computer, mathematics, agriculture and forestry, and environment.

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Vol 39, No 3 (2025)

Vol 39, No 2 (2025)

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Macrophages in the pathogenesis of psoriasis and anti-psoriatic nanotherapies

Psoriasis is a common, chronic, and inflammatory skin disease. Macrophages account for about 61.3% of the inflammatory cells infiltrating psoriatic lesions. Modulating macrophage polarization, inhibiting their infiltration, and targeting the secretion of inflammatory factors and associated inflammatory pathways by these cells can alleviate psoriasis symptoms and inflammation. Moreover, nanomaterials as novel drug carriers, offer unique advantages such as large surface area, easy modification, high biocompatibility, good biodegradability, enhanced systemic adsorption, etc. Nanomaterials have great potential for efficient drug delivery and release, as well as improving therapeutic efficacy while reducing adverse effects. By systematically addressing the role of macrophages in psoriasis pathogenesis and the potential of nanomaterials in treating psoriasis through modulating macrophages, this review enhances our understanding of the disease mechanism and holds promise for novel therapeutic breakthroughs and advancements in the future treatment of psoriasis.

Surveillance of Multi-Drug Resistant Bacterial Infections and Analysis of Changes in Colonization Trends from 2019 to 2021

Ye-ling Yang, Xiao-Hong He

Article ID: 7384
Vol 37, Issue 6, 2023

DOI: https://doi.org/10.23812/j.biol.regul.homeost.agents.20233706.328

Received: 9 July 2023; Accepted: 9 July 2023; Available online: 9 July 2023; Issue release: 9 July 2023

Abstract

Objective: The current study was undertaken to provide a scientific basis for the prevention and control of nosocomial infections by monitoring multi-drug-resistant bacterial infections and understanding changes in colonization trends. Methods: A retrospective analysis of clinical specimens from patients with multiple types of infections treated in our hospital from January 2019 to December 2021 was carried out. The samples were incubated and isolated, followed by bacterial identification using an identification instrument, and analysis of trends in distribution and variation. Results: A total of 1849 strains of bacteria of the same genus were isolated from hospital specimens collected from 2019 to 2021. A total of 103 strains of multi-drug resistant bacteria were detected, accounting for 5.57% of all strains. The multi-drug-resistant bacteria comprised 2 strains of Escherichia coli (E. coli), 13 strains of methicillin-resistant Staphylococcus aureus (MRSA), 10 strains of Klebsiella pneumoniae (K. pneumoniae), 15 strains of multidrug-resistant Acinetobacter baumannii (MDR-AB), and 63 strains of multidrug-resistant Pseudomonas aeruginosa (MDR-PA). The MDR-AB accounted for the largest proportion of multi-drug-resistant bacteria (61.17%), followed by MDR-AB (14.56%), MRSA (12.62%), K. pneumoniae (9.71%), and E. coli (1.94%). The major multi-drug resistant strains detected were from sputum specimens (77.67%), urine specimens (13.59%), secretions (4.85%), and pus and catheters (0.97%). The department with the highest level of multi-drug resistant strains was Respiratory Medicine (25.24%), followed by the intensive care unit (ICU) (22.33%) and Neurosurgery (21.36%). Conclusions: These results indicate that analysis of the types and characteristics of multi-drug resistant bacterial infections in our hospital, and implementation of targeted preventive and control measures will provide important guidelines for clinical care.

Keywords

multi-drug resistant bacterial infections;detection;colony changes;preventive and control measures

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Medical Genetics, University of Torino Medical School, Italy

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Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy

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2025-02-01

Notice of Change in Publication Schedule

In addition to the first issue that has already been published by the original publisher, there will be four more issues released this year, with scheduled publication dates in March, June, September, and December respectively.

2025-01-21

Notice: Ownership Transfer of the Journal

Starting from Volume 39 Issue 2 (2025), the ownership of Journal of Biological Regulators and Homeostatic Agents (ISSN: 0393-974X (P); 1724-6083 (O)) will be transferred from Biolife Sas to Asia Pacific Academy of Science Pte. Ltd. As of 21 January 2025, authors should make submissions to the new journal system and follow the author guidelines. Asia Pacific Academy of Science Pte. Ltd. will take over the publication of manuscripts being processed.

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