A Randomized Controlled Trial on the Effectiveness of Dextran Oral Liquid in the Treatment of Nutritional Iron Deficiency Anemia in Children

Zhiqian Sun, Fengxia Luo, Peng Feng, Wenzhen Luo, Ning Wang, Kunzu Ge, Qing Liu, Zhenggang Shi

Article ID: 7343
Vol 37, Issue 6, 2023
DOI: https://doi.org/10.23812/j.biol.regul.homeost.agents.20233706.287
Received: 9 July 2023; Accepted: 9 July 2023; Available online: 9 July 2023; Issue release: 9 July 2023

Abstract

Background & Objective: Nutritional iron deficiency anemia (NIDA) is caused by decreased hemoglobin biosynthesis due to iron deficiency. It is the most common anemia in children, and a serious danger to health. This study was aimed at investigating the efficacy of iron dextran oral solution in children with NIDA. Methods: This is a prospective randomized controlled trial on 70 children with NIDA from August 2020 to September 2021. The enrolled subjects were divided into group A and group B, with 35 children in each group. Group A received ferrous sulfate oral solution, while group B received iron dextran oral solution. Hemoglobin, mean corpuscular hemoglobin concentration (MCHC), mean corpuscular volume (MCV), clinical treatment outcomes, and adverse events were determined and compared between the 2 groups. Results: Group B had higher levels of hemoglobin, MCHC and MCV than group A (p < 0.05). Moreover, group B had significantly higher total treatment effectiveness and lower incidence of adverse reactions than group A (p < 0.05). Conclusions: The use of iron dextran oral solution is a promising strategy in the treatment of children with NIDA. It alleviates symptoms of NIDA and optimizes hemoglobin, MCHC and MCV, and it has a favorable safety profile. Therefore, iron dextran oral solution is suitable for clinical application for treatment of NIDA.


Keywords

iron dextran oral liquid;nutritional iron deficiency;anemia;children


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