TIMP1 Expression Level Predicts Worse Prognosis in Kidney Renal Clear Cell Carcinoma

Abstract

Background: Although tissue inhibitor of metalloproteinase-1 (TIMP1) is crucial for the growth of malignancies, its function in kidney renal clear cell carcinoma is still unknown. The purpose of this research was to learn more about its biological role and clinical importance in human kidney renal clear cell carcinoma (KIRC). Methods: The public database TCGA (The Cancer Genome Atlas) provided information on KIRC (Kidney Renal Clear Cell Carcinoma) patients. To assess the impact of TIMP1 on the prognosis of patients with KIRC, the Kaplan-Meier (KM) survival analysis was employed. Critical genes were analyzed and locked using the Protein-Protein Interaction (PPI) network and the Cytoscape software (version 3.7.2, Cytoscape Consortium, San Diego, CA, USA) with the cytoHubba function. To build the prediction model, univariate and multivariate Cox regression analysis were utilized. The expression level of TIMP1 was discovered using UALCAN. TIMP1 mRNA expression levels in KIRC were assessed for their predictive value using the Kaplan-Meier Plotter. Results: TIMP1 was expressed more heavily in KIRC tumor cells than in normal tissues. Different tumor subtypes, tumor grades, and tumor stages were all significantly associated with abnormal TIMP1 expression. TIMP1 was identified by the Cox proportional hazard model as a significant predictor marker for overall survival in individuals with KIRC. In addition, we found that TIMP1 is closely related to multiple tumor pathways and the collagen formation pathway. Conclusions: TIMP1 might be crucial in facilitating KIRC tumorigenesis and spread. It might serve as a KIRC prognostic predictor.