Risk Factor Analysis of the Decline in the Estimated Glomerular Filtration Rate in a Healthy Population

Abstract

Objective: Globally, the prevalence of chronic kidney disease (CKD) has increased significantly. The objective of this study was to determine the risk factors for a slight decrease in the estimated glomerular filtration rate (eGFR) in a healthy population. Methods: Participants aged between 18 to 79 who underwent a physical examination at the Health Management Center of Affiliated Hospital 2 of Nantong University (Nantong, China) were enrolled. The mild reduction in eGFR is defined as 60–90 mL/min/1.73 m². A multivariate logistic stepwise regression analysis was performed to determine the risk factors for mild eGFR decline in healthy individuals. Using the receiver operating characteristic curve, we determined the predictive value of these factors on the mildly decreased eGFR. Results: The eGFR of 7832 participants (11.8%) decreased mildly. Univariate logistic regression analysis identified male, age, systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting blood glucose, uric acid (UA), total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C) as potential risk factors for a mildly decreased eGFR. Multivariate logistic analysis identified male, age, DBP, uric acid, and LDL-C as independent risk factors for eGFR decline. Conclusions: In a healthy population, the prevalence of a slight decline in eGFR was 11.8%, and (male) gender, age, DBP, UA, and LDL-C were all independent risk factors for a slight decline in eGFR.