MicroRNA-135-5p and MicroRNA-34c-5p are Potential Diagnostic Markers of Nerve Injury Following Intracerebral Hemorrhage

Abstract

Background: MicroRNAs (miRNAs), modulatory elements of translation are linked with the pathogenesis of various cerebrovascular illnesses, including intracerebral hemorrhage (ICH), and are considered promising prognostic biomarkers in diseases. The aim of this study was to investigate the diagnostic value of miR-135-5p and miR-34c-5p in predicting nerve injury after ICH. Methods: Serum miR-135-5p and miR-34c-5p were checked in 68 patients with acute spontaneous basal ganglia hemorrhage and 68 healthy controls. A multivariate analysis was carried out to assess the association of miR-135-5p and miR-34c-5p with prognosis, National Institutes of Health Stroke Scale (NIHSS) score as well as bleeding severity of hematoma volume indication. The diagnostic value was evaluated using receiver operating characteristic (ROC) curve. Results: miR-135-5p and miR-34c-5p were significantly reduced in the serum of patients and independently associated with NIHSS score and hematoma volume. miR-135-5p and miR-34c-5p expression was correlated with the poor prognosis of patients. Analyzing the area under the curve (AUC) showed that serum miR-135-5p and miR-34c-5p have promising diagnostic values. Conclusions: Serum miR-135-5p and miR-34c-5p are associated with the severity and clinical outcome of ICH patients, confirming that the two are potential prognostic biomarkers of ICH.