The Effect of Penehyclidine Hydrochloride on the Respirational Mechanism and Oxidative Stress Responsiveness of Rats with Chronic Obstructive Pulmonary Disease during Induced Ventilation

Abstract

Objective: This study aimed to assess the effects of penehyclidine hydrochloride on rats diagnosed with chronic obstructive pulmonary disease (COPD) concerning their respirational mechanism and oxidative stress responsiveness during induced ventilation. Methods: A total of 36 rats in the modeling group were randomly divided into a model group (group M), a model + normal saline group (group N), and a penehyclidine hydrochloride group (group H) with 12 rats in each. Another 12 rats were randomly selected from a normoxia group as the control group (group C). After intubation, the rats in each group were mechanically ventilated. Group H was given a real-time intravenous injection of penehyclidine hydrochloride 1.0 mg/kg, while groups C and N were given a real-time intravenous injection of a similar volume of normal saline. Peak airway pressure (Ppeak) was monitored immediately after the injection (T0), 30 min after the injection (T1), 60 min after the injection (T2), and 120 min after the injection (T3); The rats were collected after mechanical ventilation lasting a total of 120 min. The partial pressure of oxygen (PaO₂) and the partial pressure of carbon dioxide (PaCO₂) were measured, and malondialdehyde (MDA) and superoxide dismutase (SOD) lung tissue changes were observed. Results: Typical pathological COPD changes were found in the lung tissue of the rats in groups M, N, and H. Compared with group C, the Ppeak, PaCO₂, and MDA levels in groups M, N, and H had increased (p < 0.05), while the levels of PaO₂ and SOD had decreased (p < 0.05). Compared with group N, the Ppeak, PaCO₂, and MDA levels in group H had decreased (p < 0.05), and the levels of PaO₂ and SOD had increased (p < 0.05). Conclusions: Penehyclidine hydrochloride can reduce airway resistance and improve pulmonary ventilation in COPD rats during mechanical ventilation. It can also decrease the oxidative stress level during mechanical ventilation and lessen lung membrane damage.