Development of a Diagnostic Model Based on Immune-Related Differential Genes in Membranous Nephropathy

Guangda Xin; Guangyu Zhou

doi:10.23812/j.biol.regul.homeost.agents.20233704.175

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Asia Pacific Academy of Science Pte. Ltd. (APACSCI) specializes in international journal publishing. APACSCI adopts the open access publishing model and provides an important communication bridge for academic groups whose interest fields include engineering, technology, medicine, computer, mathematics, agriculture and forestry, and environment.

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Macrophages in the pathogenesis of psoriasis and anti-psoriatic nanotherapies

Psoriasis is a common, chronic, and inflammatory skin disease. Macrophages account for about 61.3% of the inflammatory cells infiltrating psoriatic lesions. Modulating macrophage polarization, inhibiting their infiltration, and targeting the secretion of inflammatory factors and associated inflammatory pathways by these cells can alleviate psoriasis symptoms and inflammation. Moreover, nanomaterials as novel drug carriers, offer unique advantages such as large surface area, easy modification, high biocompatibility, good biodegradability, enhanced systemic adsorption, etc. Nanomaterials have great potential for efficient drug delivery and release, as well as improving therapeutic efficacy while reducing adverse effects. By systematically addressing the role of macrophages in psoriasis pathogenesis and the potential of nanomaterials in treating psoriasis through modulating macrophages, this review enhances our understanding of the disease mechanism and holds promise for novel therapeutic breakthroughs and advancements in the future treatment of psoriasis.

Development of a Diagnostic Model Based on Immune-Related Differential Genes in Membranous Nephropathy

Guangda Xin, Guangyu Zhou

Article ID: 7231
Vol 37, Issue 4, 2023

DOI: https://doi.org/10.23812/j.biol.regul.homeost.agents.20233704.175

Received: 9 May 2023; Accepted: 9 May 2023; Available online: 9 May 2023; Issue release: 9 May 2023

Abstract

Objective: Emerging evidence has confirmed the involvement of infiltrating immune cells and immune-related genes in membranous nephropathy (MN) pathogenesis. This study aimed to explore immune-related signatures for risk prediction in patients with MN. Methods: Transcriptome sequencing data associated with MN were collected from public databases to screen for differentially expressed genes (DEGs). Immune cell infiltration was evaluated using Cell-type Identification by Estimating Relative Subsets of RNA Transcripts (CIBERSORT) software (Stanford University, San Francisco, CA, USA), and immune-related genes were screened. Functional enrichment analysis was performed, followed by construction of regulatory networks. The optimal signature genes were identified using multiple bioinformatics methods. A nomogram model was established and validated for the diagnostic prediction of patients with MN. Co-expression associations between hub genes and the proportion of immune cells were investigated. Results: A total of 576 DEGs were identified between the MN and control samples. Eight immune cell types with differential proportions were identified and 325 DEGs were selected as immune-related genes. These DEGs were primarily involved in cell adhesion, inflammatory response, complement and coagulation cascades, cytokine-cytokine receptor interactions, and HTLV-I (human T-lymphotropic virus type I) infection. Finally, a total of eight immune genes were selected as the optimal biomarkers associated with MN, such as APOBEC3F, IL1RL1, MDK, and NR4A3. A diagnostic nomogram model consisting of eight genes was established and verified using the combined and validation datasets. There was a significant correlation between the signature genes and infiltrated immune cells (p < 0.05). Conclusions: Eight immune-related genes that may serve as potential diagnostic biomarkers for MN were identified. A nomogram model incorporating signature genes is convenient for facilitating individual risk prediction of MN.

Keywords

membranous nephropathy;differentially expressed genes;immune cell infiltration;diagnostic model

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Dr. Fabio Malavasi

Medical Genetics, University of Torino Medical School, Italy

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Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy

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2025-02-01

Notice of Change in Publication Schedule

In addition to the first issue that has already been published by the original publisher, there will be four more issues released this year, with scheduled publication dates in March, June, September, and December respectively.

2025-01-21

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Starting from Volume 39 Issue 2 (2025), the ownership of Journal of Biological Regulators and Homeostatic Agents (ISSN: 0393-974X (P); 1724-6083 (O)) will be transferred from Biolife Sas to Asia Pacific Academy of Science Pte. Ltd. As of 21 January 2025, authors should make submissions to the new journal system and follow the author guidelines. Asia Pacific Academy of Science Pte. Ltd. will take over the publication of manuscripts being processed.

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