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Implications of Esophageal Cancer Susceptibility Gene Testing for Subsequent Treatment
Vol 37, Issue 4, 2023
Abstract
Background: Esophageal cancer is a malignant tumor of the upper gastrointestinal tract caused by environmental and genetic factors. Genetic polymorphisms and expression variations of esophageal cancer susceptibility genes are key influencing factors of individual susceptibility to tumors. Due to the insufficient screening of risk factors for esophageal cancer by traditional epidemiology, identification of esophageal cancer risks at the molecular level may benefit esophageal cancer prevention and therapy. The p53 gene, Fragile Histidine Triad Diadenosine Triphosphatase (FHIT) gene, P16 gene, mismatch repair gene, and Phospholipase C Epsilon 1 (PLCE1) gene have been heavily studied in recent years given their roles in the genesis and progression of esophageal cancer. Therefore, this paper briefly outlines the significance of esophageal cancer susceptibility gene testing for subsequent treatment, providing a feasible pathway for early diagnosis, prognosis assessment and gene therapy of esophageal cancer.
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Copyright (c) 2023 Ningbin Du, Yunxia Niu, Zuhao Tian, Yongqi Hao, Jinying Meng
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Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy