Periostin as a Potential Biomarker of Acute Myocardial Infarction

Abstract

Background: This study aimed to evaluate the correlation between the level of periostin (POSTN) in plasma and acute myocardial infarction (AMI). Methods: Patients with a definite diagnosis of AMI were included in the present study, and normal controls were established. The levels of POSTN in the peripheral blood leukocytes (WBCs) of patients with AMI within 24 h of infarction were measured by polymerase chain reaction. The plasma levels of POSTN within 24 h, on day 7, and on day 30 after AMI were measured by enzyme-linked immunosorbent assay, and the data were statistically analyzed. Results: The expressions of POSTN in plasma and WBCs were significantly lower in patients with AMI within 24 h. The plasma levels of POSTN in patients with AMI were the lowest at 24 h after infarction;They increased significantly on day 7 and approached normal levels on day 30. The most rapid elevation of POSTN occurred within 7 d. When the POSTN level was 302.3 ng/mL, the sensitivity and specificity for the diagnosis of AMI were 73% and 85%, respectively. Conclusions: The plasma level of POSTN was significantly lower during the early stage of AMI, and it changed with the development of the infarction. The plasma level of POSTN within 24 h might be of diagnostic value for AMI.