Value of Combination of Computed Tomography, Serum Homocysteine, Cystatin C and Uric Acid in the Diagnosis of Hypertensive Left Ventricular Hypertrophy

Abstract

Objective: This study aimed to assess the diagnostic value of combined detection of computed tomography (CT), serum homocysteine (Hcy), cystatin C (Cyst-C), and uric acid (UA) concentrations for hypertensive left ventricular hypertrophy. Methods: The present study matched 50 patients with primary hypertension without left ventricular hypertrophy (control group) with 50 patients with primary hypertension with left ventricular hypertrophy (HLVH group) from March 2019 to May 2020. The serum Hcy, Cyst-C, UA levels, IVST (interventricular septum thickness), LVDD (left ventricular end-diastolic diameter), LVPWT (left ventricular posterior wall thickness), LVEF (left ventricular ejection fraction), LVFS (left ventricular fraction shortening), and blood lipid levels were compared between the two groups. The specificity, sensitivity, and accuracy of CT combined with serum Hcy, Cyst-C, and UA levels were compared between the two groups, and the correlation of serum Hcy, Cyst-C, and UA levels with HLVH was analyzed. Results: Patients with left ventricular hypertrophy showed poorer outcomes of serum Hcy, Cyst-C, UA levels, IVST, LVDD, LVPWT, LVEF, LVFS, and blood lipid levels versus those without (p < 0.05). Combined detection was associated with higher specificity, sensitivity, and accuracy versus single detection (p < 0.05). Serum Hcy, Cyst-C, and UA levels were positively correlated with hypertensive left ventricular hypertrophy (p < 0.05). Conclusions: Hybrid detection of CT and serum Hcy, Cyst-C, and UA levels substantially improve the diagnostic accuracy for hypertensive left ventricular hypertrophy.