Complement C1 Tumor Necrosis Factor-Related Protein 1 is Related to Glucose/Lipid Metabolism in Polycystic Ovary Syndrome Patients

Abstract

Objectives: Most patients with polycystic ovary syndrome (PCOS) have glucose/lipid metabolism. Complement C1 tumor necrosis factor-related protein 1 (CTRP1) is an indicator of glucose/lipid metabolism in many diseases. However, the correlation between CTRP1 and PCOS is not clear. Method: This is a cross-sectional study. CTRP1 plasma concentration level in 210 PCOS and 316 non-PCOS patients undergoing in-vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) was assessed. Among PCOS patients 2 groups were formed depending on the presence of insulin resistance, the PCOS-IR (insulin resistance) (n = 84) and PCOS-NIR (non-IR) groups (n = 126). The inflammatory markers, antioxidant enzyme levels of follicular fluid and CTRP1 levels in PCOS group and non-PCOS group were compared. The levels of inflammation markers and antioxidant enzymes in follicular fluid and CTRP1 levels were compared between PCOS-IR group and PCOS-NIR group. Pearson correlation analysis was used to analyze the relationship between CTRP1 and glucose/lipid metabolism and gonadotropin dose in PCOS patients. Results: PCOS patients exhibited significantly higher plasma concentration of CTRP1 than non-PCOS patients (p < 0.001). Besides, the CTRP1 level was significantly elevated in PCOS-IR compared to PCOS-NIR group (p < 0.001). CTRP1 was strongly associated with markers of dyslipidemia and high gonadotropin dose (p < 0.05). In addition, CTRP1 expression level in the follicular fluid was higher in PCOS-IR sufferers and had a negative effect on inflammatory response, peroxidation, and antioxidant enzyme index. Conclusions: PCOS patients, especially PCOS-IR patients, show significantly CTRP1 up-regulation. CTRP1 may serve as a new marker for PCOS-IR patients. In addition, there is a correlation between the circulation of CTRP1 and glucose/lipid metabolic disorder in PCOS patients.