Molecular Mechanism of Qiju Decoction for Acute Lung Injury Based on Network Pharmacology

Wang Tong; Junchao Yang

doi:10.23812/j.biol.regul.homeost.agents.20233702.80

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Asia Pacific Academy of Science Pte. Ltd. (APACSCI) specializes in international journal publishing. APACSCI adopts the open access publishing model and provides an important communication bridge for academic groups whose interest fields include engineering, technology, medicine, computer, mathematics, agriculture and forestry, and environment.

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2025

Vol 39, No 3 (2025)

Vol 39, No 2 (2025)

Vol 39, No 1 (2025)

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Macrophages in the pathogenesis of psoriasis and anti-psoriatic nanotherapies

Psoriasis is a common, chronic, and inflammatory skin disease. Macrophages account for about 61.3% of the inflammatory cells infiltrating psoriatic lesions. Modulating macrophage polarization, inhibiting their infiltration, and targeting the secretion of inflammatory factors and associated inflammatory pathways by these cells can alleviate psoriasis symptoms and inflammation. Moreover, nanomaterials as novel drug carriers, offer unique advantages such as large surface area, easy modification, high biocompatibility, good biodegradability, enhanced systemic adsorption, etc. Nanomaterials have great potential for efficient drug delivery and release, as well as improving therapeutic efficacy while reducing adverse effects. By systematically addressing the role of macrophages in psoriasis pathogenesis and the potential of nanomaterials in treating psoriasis through modulating macrophages, this review enhances our understanding of the disease mechanism and holds promise for novel therapeutic breakthroughs and advancements in the future treatment of psoriasis.

Molecular Mechanism of Qiju Decoction for Acute Lung Injury Based on Network Pharmacology

Wang Tong, Junchao Yang

Article ID: 7152
Vol 37, Issue 2, 2023

DOI: https://doi.org/10.23812/j.biol.regul.homeost.agents.20233702.80

Received: 11 March 2023; Accepted: 11 March 2023; Available online: 11 March 2023; Issue release: 11 March 2023

Abstract

Background: To analyze the pharmacological effects and molecular mechanisms of Qiju Decoction to treat acute lung injury (ALI) based on network pharmacology. Methods: The main chemical components of Qiju Decoction were collected from Traditional Chinese Medicine Systems Pharmacology Database. Analysis of the Platform, literature collection and screening of the active components and their targets were performed according to pharmacokinetics. Targets related to acute lung injury (ALI) were collected from Genecards, OMIM (Online Mendelian Inheritance in Man), DrugBank and TTD (Therapeutic Target Database). Network of protein-protein interactions were established using STRING database, the picture of the interconnection of Chinese medicine ingredients, targets and pathways was constructed using Cytoscape software. Metaspace database was used for Gene ontology (GO) analysis, and kyoto encyclopedia of genes and genomes (KEGG) analysis. Results: The core active ingredients of Qiju Decoction to treat acute lung injury were quercetin, kaempferol, Luteolin, Arachidonic acid, etc. The core targets of Qiju Decoction to treat ALI were ALB (Albumin), AKT1 (RAC-alpha serine/Threonine-protein kinase), TP53 (Cellular tumor antigen p53), TNF (Tumor necrosis factor), IL-6 (Interleukin-6), VEGFA (Vascular endothelial growth factor A), CASP3 (Caspase-3), EGFR (Epidermal growth factor receptor), IL-1β (Interleukin-1 beta), JUN (Transcription factor Jun), STAT3 (Signal transducer and activator of transcription 3), MAPK (Mitogen-activated protein kinase), etc. The biological pathways of Qiju Decoction to treat ALI are mainly PI3K-Akt (Phosphatidylinositol 3 kinase/Protein kinase B) signaling pathway, MAPK signaling pathway and TNF signaling pathway, which functions are mainly to regulate intracellular inflammatory response and oxidative stress response, etc. Conclusions: This study revealed the multi-component, multi-target, and multi-pathway mechanism of Qiju Decoction to treat acute lung injury. It provides the basis for the clinical development and utilization of Qiju Decoction.

Keywords

QiJu Decoction;acute lung injury;PI3K-Akt

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Editor-in-Chief

Dr. Fabio Malavasi

Medical Genetics, University of Torino Medical School, Italy

Co-Editor-in-Chief

Prof. Marcello Iriti

Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy

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2025-02-01

Notice of Change in Publication Schedule

In addition to the first issue that has already been published by the original publisher, there will be four more issues released this year, with scheduled publication dates in March, June, September, and December respectively.

2025-01-21

Notice: Ownership Transfer of the Journal

Starting from Volume 39 Issue 2 (2025), the ownership of Journal of Biological Regulators and Homeostatic Agents (ISSN: 0393-974X (P); 1724-6083 (O)) will be transferred from Biolife Sas to Asia Pacific Academy of Science Pte. Ltd. As of 21 January 2025, authors should make submissions to the new journal system and follow the author guidelines. Asia Pacific Academy of Science Pte. Ltd. will take over the publication of manuscripts being processed.

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