Correlation between Hydrocephalus and Sleep Rhythm Disturbance Post Pineal Lesion Surgery

Abstract

Background: The association between sleep-wake cycles disorder and pineal gland lesions was rarely reported, while a growing number of literatures showed that patients have varying degrees of sleep rhythm disturbances. Individuals with these complications have to plan a life-long regimen to control their progressive illness. Effective assessment and treatment of the complication is urgently needed. Methods: 17 patients suffered from pineal lesions were distributed in two groups based on Glasgow Outcome Scale (GOS): Group 1: GOS <9 (N = 11);Group 2: GOS >9 (N = 6). Clinical data were collected 12 months after operation. The medical records were reviewed, the demographic information was extracted, and the clinical symptoms, cognitive level (coma, lethargy), hormonal results, and neurologic complications were recorded. Hydrocephalus was revealed in all patients by brain computed tomography (CT) scan. Results: The less measured values of hydrocephalus were observed in G2 patients under ventricular shunt treatment. Statistical analyses indicated that hydrocephalus was related to GOS and the score of the National Institutes of Health stroke scale (NIHSS) (p < 0.05). The mild fever (37.3–38.2 °C) was associated with pineal damage (p < 0.05). Conclusions: Patients’ recovery after pineal lesions surgery was affected by pineal damage or compression. Clinicians ought to pay attention to clinical profiles of these conditions and recommend ventricular shunt treatment accordingly.