LncRNA DNM3OS Promotes Tumorigenesis of Liver Cancer by Inducing FOXO3a Methylation via Interacting with DNMT1

Caixia Li; Bing Chen; Hai Yu; Yonggang Zhang

doi:10.23812/j.biol.regul.homeost.agents.20233701.11

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Asia Pacific Academy of Science Pte. Ltd. (APACSCI) specializes in international journal publishing. APACSCI adopts the open access publishing model and provides an important communication bridge for academic groups whose interest fields include engineering, technology, medicine, computer, mathematics, agriculture and forestry, and environment.

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2025

Vol 39, No 3 (2025)

Vol 39, No 2 (2025)

Vol 39, No 1 (2025)

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Macrophages in the pathogenesis of psoriasis and anti-psoriatic nanotherapies

Psoriasis is a common, chronic, and inflammatory skin disease. Macrophages account for about 61.3% of the inflammatory cells infiltrating psoriatic lesions. Modulating macrophage polarization, inhibiting their infiltration, and targeting the secretion of inflammatory factors and associated inflammatory pathways by these cells can alleviate psoriasis symptoms and inflammation. Moreover, nanomaterials as novel drug carriers, offer unique advantages such as large surface area, easy modification, high biocompatibility, good biodegradability, enhanced systemic adsorption, etc. Nanomaterials have great potential for efficient drug delivery and release, as well as improving therapeutic efficacy while reducing adverse effects. By systematically addressing the role of macrophages in psoriasis pathogenesis and the potential of nanomaterials in treating psoriasis through modulating macrophages, this review enhances our understanding of the disease mechanism and holds promise for novel therapeutic breakthroughs and advancements in the future treatment of psoriasis.

LncRNA DNM3OS Promotes Tumorigenesis of Liver Cancer by Inducing FOXO3a Methylation via Interacting with DNMT1

Caixia Li, Bing Chen, Hai Yu, Yonggang Zhang

Article ID: 7059
Vol 37, Issue 1, 2023

DOI: https://doi.org/10.23812/j.biol.regul.homeost.agents.20233701.11

Received: 8 February 2023; Accepted: 8 February 2023; Available online: 8 February 2023; Issue release: 8 February 2023

Abstract

Background and Objective: DNM3OS (Dynamin 3 Opposite Strand/Antisense RNA) is a hepatocellular carcinoma (HCC)-related long noncoding RNA. We aim to investigate whether DNM3OS regulates the growth of HCC cells by the DNA methyltransferase 1 (DNMT1)/Forkhead box O3a (FOXO3a) pathway. Methods: LncRNAs related to liver cancer were identified by searching the LncRNADisease v2.0 database. DNM3OS and FOXO3a expression levels were detected through qRT-PCR in clinical specimens, as well as in THLE-2, SK-HeP1, and Huh-7 cells. CHIP (Chromatin Immunoprecipitation) and RIP (RNA immunoprecipitation) assays were used to detect the interaction of DNM3OS and methyltransferase. A tumor formation experiment was used to detect growth of HCC cells into a tumor in nude mice. Results: In liver cancer patients, DNM3OS was highly expressed whilst the expression of FOXO3a was low. DNM3OS promoted the methylation in the FOXO3a promoter region and inhibited the transcription of FOXO3a. Conclusions: The lncRNA DNM3OS works as an oncogene that encourages liver cancer progression by promoting methylation of the FOXO3a promoter via DNMT1. Our research provides new clues for clarifying the molecular mechanisms underlying HCC.

Keywords

HCC;DNM3OS;DNMT1;FOXO3a;methylation;apoptosis

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Dr. Fabio Malavasi

Medical Genetics, University of Torino Medical School, Italy

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Prof. Marcello Iriti

Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy

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2025-02-01

Notice of Change in Publication Schedule

In addition to the first issue that has already been published by the original publisher, there will be four more issues released this year, with scheduled publication dates in March, June, September, and December respectively.

2025-01-21

Notice: Ownership Transfer of the Journal

Starting from Volume 39 Issue 2 (2025), the ownership of Journal of Biological Regulators and Homeostatic Agents (ISSN: 0393-974X (P); 1724-6083 (O)) will be transferred from Biolife Sas to Asia Pacific Academy of Science Pte. Ltd. As of 21 January 2025, authors should make submissions to the new journal system and follow the author guidelines. Asia Pacific Academy of Science Pte. Ltd. will take over the publication of manuscripts being processed.

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