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Efficacy of Songling Xuemaikang Capsule on Essential Hypertension, as Monitored on Ambulatory Basis: A Systematic Review and a Meta-Analysis of Randomized Controlled Trials (RCTs)
Vol 37, Issue 1, 2023
Abstract
Objective: To investigate the efficacy of Songling Xuemaikang Capsule (SXC) on essential hypertension, as monitored on ambulatory basis. Methods: Relevant randomized controlled trials (RCTs) were obtained via a systematic search of several databases. The results were pooled with a randomized or a fixed-effect model, according to the heterogeneity. The Cochrane risk of bias assessment tool was used for quality assessment. Results: Thirteen RCTs with 1092 essential hypertension (EH) patients were included in the meta-analysis. Compared with Losartan, SXC was less effective at reducing 24-hour average systolic blood pressure (ASBP, weighted mean difference (WMD): 1.80 mmHg, p = 0.04). SXC combined with other anti-hypertensives significantly reduced ADBP (average diastolic BP) during the daytime (WMD: –1.24 mmHg, p < 0.0001) and systolic blood pressure variability (SBPV) during the nighttime (SMD: –0.58, p < 0.00001), compared to anti-hypertensives alone. Subgroup analyses showed that the combination of SXC and Amlodipine achieved significantly better control of 24-hour ASBP and ADBP (p < 0.05) compared to Amlodipine alone. The combination of SXC and an angiotensin converting enzyme inhibitor (ACEI) achieved significantly better control of 24-hour ASBP and ASBP during both the daytime and nighttime, compared to ACEI alone (p < 0.01). Conclusions: The combination of SXC and Amlodipine Besylate significantly reduced 24-hour ASBP and ADBP. Due to the modest quality of the RCTs included in this meta-analysis, more rigorously designed studies are needed.
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Copyright (c) 2023 Huile Li, Hongguan Zhang, Yanyou Cen, Yude Liu
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Medical Genetics, University of Torino Medical School, Italy

Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy