Salmonella Shows Anti-Cancer Influences in Human Colon Cancer Cells by Promoting Apoptosis and G0/G1 Phase Cell Cycle Arrest via PI3K/AKT/mTOR Pathway Inhibition

Bingling Zhang; Ting Fang; Sheng Li; Lan Xiang

doi:10.23812/j.biol.regul.homeost.agents.20223606.228

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Asia Pacific Academy of Science Pte. Ltd. (APACSCI) specializes in international journal publishing. APACSCI adopts the open access publishing model and provides an important communication bridge for academic groups whose interest fields include engineering, technology, medicine, computer, mathematics, agriculture and forestry, and environment.

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2025

Vol 39, No 3 (2025)

Vol 39, No 2 (2025)

Vol 39, No 1 (2025)

Featured Articles

Macrophages in the pathogenesis of psoriasis and anti-psoriatic nanotherapies

Psoriasis is a common, chronic, and inflammatory skin disease. Macrophages account for about 61.3% of the inflammatory cells infiltrating psoriatic lesions. Modulating macrophage polarization, inhibiting their infiltration, and targeting the secretion of inflammatory factors and associated inflammatory pathways by these cells can alleviate psoriasis symptoms and inflammation. Moreover, nanomaterials as novel drug carriers, offer unique advantages such as large surface area, easy modification, high biocompatibility, good biodegradability, enhanced systemic adsorption, etc. Nanomaterials have great potential for efficient drug delivery and release, as well as improving therapeutic efficacy while reducing adverse effects. By systematically addressing the role of macrophages in psoriasis pathogenesis and the potential of nanomaterials in treating psoriasis through modulating macrophages, this review enhances our understanding of the disease mechanism and holds promise for novel therapeutic breakthroughs and advancements in the future treatment of psoriasis.

Salmonella Shows Anti-Cancer Influences in Human Colon Cancer Cells by Promoting Apoptosis and G0/G1 Phase Cell Cycle Arrest via PI3K/AKT/mTOR Pathway Inhibition

Bingling Zhang, Ting Fang, Sheng Li, Lan Xiang

Article ID: 7054
Vol 36, Issue 6, 2022

DOI: https://doi.org/10.23812/j.biol.regul.homeost.agents.20223606.228

Received: 8 January 2023; Accepted: 8 January 2023; Available online: 8 January 2023; Issue release: 8 January 2023

Abstract

Background: Colon cancer is an aggressive digestive system cancer. Increasing research suggests that the bacteria Salmonella is associated with human cancers and could restrain tumor growth. However, the effect of Salmonella in colon cancer has been puzzling. Methods: Salmonella enterica serovar choleraesuis vaccine strain was used for this research to estimate the function of Salmonella in colon cancer. Function experiments were utilized for analyzing cell apoptosis and proliferation. Proteins levels in cells were assessed by western blot. Results: It was observed that enhanced Salmonella concentration was negatively correlated with the viability of colon cancer cells. Cell cycle was arrested following treatment with Salmonella in G0/G1 phase. Moreover, it was verified that at cellular level Salmonella could restrain tumor cell proliferation and restrain phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling activity. Conclusions: Salmonella exhibits anti-cancer properties via restraint of the PI3K/AKT/mTOR pathway in colon cancer. This work brings new insights for colon cancer treatment.

Keywords

Salmonella;cell apoptosis;cell cycle;colon cancer;PI3K/AKT/mTOR pathway

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Dr. Fabio Malavasi

Medical Genetics, University of Torino Medical School, Italy

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Prof. Marcello Iriti

Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy

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2025-02-01

Notice of Change in Publication Schedule

In addition to the first issue that has already been published by the original publisher, there will be four more issues released this year, with scheduled publication dates in March, June, September, and December respectively.

2025-01-21

Notice: Ownership Transfer of the Journal

Starting from Volume 39 Issue 2 (2025), the ownership of Journal of Biological Regulators and Homeostatic Agents (ISSN: 0393-974X (P); 1724-6083 (O)) will be transferred from Biolife Sas to Asia Pacific Academy of Science Pte. Ltd. As of 21 January 2025, authors should make submissions to the new journal system and follow the author guidelines. Asia Pacific Academy of Science Pte. Ltd. will take over the publication of manuscripts being processed.

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