Relationship between the Apolipoprotein B/A1 Ratio, Apolipoprotein F with Myocardial Infarction in Patients with CHD

Abstract

Objective: To evaluate the relationship between the apolipoprotein B (ApoB)/ apolipoprotein A1 (ApoAI) ratio and apolipoprotein F (ApoF) with myocardial infarction (MI) in patients with coronary heart disease (CHD). Methods: 231 patients with CHD were screened for inclusion. Among them, 178 patients with MI were included in the MI group, and 53 patients without MI were included in the non-MI (n-MI) group. The laboratory indexes such as ApoB/ApoAI and ApoF of coronary heart disease patients were recorded, and the laboratory indexes and basic data of MI group and n-MI group were compared and analyzed. The relationship between the value ApoB/ApoAI and ApoF with MI in CHD patients was assessed using multivariate logistic regression analysis. Receiver operating characteristic (ROC) curve was used to find best cut-off values of parameters related with the occurrence of MI. Results: Sex, age, body mass index (BMI), smoking, drinking, hypertension or diabetes was similar between groups (p > 0.05). ApoF level was lower, and ApoB, ApoB/ApoAI, uric acid (UA), low density liptein (LDL) levels and Gensini score were higher (p < 0.05) in the MI group compared to the n-MI group. ApoAI, blood urea nitrogen (BUN), creatinine (Cr), triglyceride (TG), total cholesterol (TC) or high density liptein (HDL) was similar between groups (p > 0.05). Logistic regression analysis showed that ApoF levels acted as a protective factor for MI, and the ApoB/ApoAI was a risk factor for MI (p < 0.05). However, ApoB, UA, and LDL levels did not significantly correlate with MI (p > 0.05). ROC analysis showed that the area under the curve (AUC) of ApoF to determine MI was 0.732, and the best cut-off value was ≤56.19 µg/mL. The AUC of ApoB/ApoAI to determine MI was 0.701, and the best cut-off value was >1.03. Finally, the AUC of the two combined to determine MI was 0.816 (p < 0.05). Conclusions: Elevated ApoB/ApoAI and decreased ApoF are independent factors impacting the occurrence of MI in patients with coronary artery disease, among which elevated ApoB/ApoAI acts as a risk factor, and elevated ApoF acts as a protective factor. The risk of MI is higher when ApoB/ApoAI is ≤56.19 µg/mL and when ApoF is >1.03.