The Effect and Mechanism of Action of Oridonin on Carbon Tetrachloride-Induced Liver Injury&#894; An Animal Study

Si-Yu Yu; Xiang-Yu Shan; Yu-Jie Wu; Cheng Ji

doi:10.23812/j.biol.regul.homeost.agents.20223606.205

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Asia Pacific Academy of Science Pte. Ltd. (APACSCI) specializes in international journal publishing. APACSCI adopts the open access publishing model and provides an important communication bridge for academic groups whose interest fields include engineering, technology, medicine, computer, mathematics, agriculture and forestry, and environment.

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Macrophages in the pathogenesis of psoriasis and anti-psoriatic nanotherapies

Psoriasis is a common, chronic, and inflammatory skin disease. Macrophages account for about 61.3% of the inflammatory cells infiltrating psoriatic lesions. Modulating macrophage polarization, inhibiting their infiltration, and targeting the secretion of inflammatory factors and associated inflammatory pathways by these cells can alleviate psoriasis symptoms and inflammation. Moreover, nanomaterials as novel drug carriers, offer unique advantages such as large surface area, easy modification, high biocompatibility, good biodegradability, enhanced systemic adsorption, etc. Nanomaterials have great potential for efficient drug delivery and release, as well as improving therapeutic efficacy while reducing adverse effects. By systematically addressing the role of macrophages in psoriasis pathogenesis and the potential of nanomaterials in treating psoriasis through modulating macrophages, this review enhances our understanding of the disease mechanism and holds promise for novel therapeutic breakthroughs and advancements in the future treatment of psoriasis.

The Effect and Mechanism of Action of Oridonin on Carbon Tetrachloride-Induced Liver Injury; An Animal Study

Si-Yu Yu, Xiang-Yu Shan, Yu-Jie Wu, Cheng Ji

Article ID: 7031
Vol 36, Issue 6, 2022

DOI: https://doi.org/10.23812/j.biol.regul.homeost.agents.20223606.205

Received: 8 January 2023; Accepted: 8 January 2023; Available online: 8 January 2023; Issue release: 8 January 2023

Abstract

Purpose: The aim of this study was to look into the effect and mechanism of action of oridonin (Ori) in carbon tetrachloride (CCL4)-induced liver injury in rats. Methods: 24 adult male Sprague Dawley (SD) rats were divided into four groups at random: Control, Ori, CCL4, and CCL4 + Ori. In addition to body and liver weights as well as blood tests, real-time quantitative reverse transcription PCR (qRT-PCR) was used to detect the mitochondrial deoxyribonucleic acid (DNA) level in the liver tissue of rats, and the protein expression levels of NAD (P) H quinone oxidoreductase 1 (NQO1), heme oxygenase-1 (HO-1) and the nuclear erythroid-2-related factor 2 (Nrf2) in the liver tissues of the rats were checked for using western blot. Results: Ori showed antioxidant and hepatoprotective effects in rats with CCL4-induced liver injury and significantly improved mitochondrial function in rats with CCL4-induced liver injury. Additionally, Ori significantly alleviated CCL4-induced liver injury in rats, by activating the Nrf2/HO-1/NQO1 pathway. Conclusions: Ori may attenuate CCL4-induced liver injury in rats via improving mitochondrial function and activating the Nrf2/HO-1/NQO1 pathway, as well as having hepatoprotective and anti-oxidative effects.

Keywords

oridonin;liver injury;oxidative stress;mitochondrial function;nuclear erythroid-2-related factor 2/heme oxygenase-1/NAD (P) H quinone oxidoreductase 1 pathway

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Medical Genetics, University of Torino Medical School, Italy

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Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy

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2025-02-01

Notice of Change in Publication Schedule

In addition to the first issue that has already been published by the original publisher, there will be four more issues released this year, with scheduled publication dates in March, June, September, and December respectively.

2025-01-21

Notice: Ownership Transfer of the Journal

Starting from Volume 39 Issue 2 (2025), the ownership of Journal of Biological Regulators and Homeostatic Agents (ISSN: 0393-974X (P); 1724-6083 (O)) will be transferred from Biolife Sas to Asia Pacific Academy of Science Pte. Ltd. As of 21 January 2025, authors should make submissions to the new journal system and follow the author guidelines. Asia Pacific Academy of Science Pte. Ltd. will take over the publication of manuscripts being processed.

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