Effects of Mild Hypothermia Therapy on Oxidative Stresses and Immune Functions in Patients after Successful Cardiopulmonary Resuscitation

Abstract

Background: Oxidative stress and immune abnormalities in cardiac arrest (SCA) patients undergoing cardiopulmonary resuscitation (CPR) seriously threaten their survival. The mild hypothermia therapy has been applied in patients after successful cardiopulmonary resuscitation. However, the function of mild hypothermia therapy on oxidative stress and immune regulation in SCA patients remains unclear. Methods: A controlled clinical trial was performed to evaluate the effects of mild hypothermia therapy on the management of SCA patients in intensive care unit (ICU) post CPR. Participants diagnosed with SCA received CPR and were divided in to mild hypothermia (MH) group (n = 46) and control group (n = 46). They received standard ICU management or ICU management plus mild hypothermia therapy respectively. Glasgow coma scale (GCS) and sequential organ failure assessment (SOFA) were performed. The oxidative stress and immunological markers were examined. Results: Mild hypothermia therapy statistically inhibited the total incidence of complications in SCA patient post-CPR. Mild hypothermia therapy upregulated the GCS score and downregulated the SOFA score at 18 h and 36 h post CPR. Mild hypothermia therapy inhibited the oxidative stress of patients with SCA post-CPR. The IgA (immunoglobulins A), IgG (immunoglobulins G) and IgM (immunoglobulins M) were upregulated statistically post mild hypothermia. Conclusions: Mild hypothermia therapy has protective effects on oxidative stresses and immune functions of SCA patient post-CPR.