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Fibulin-5 Gene Attenuates Inflammation via the Calcitonin Gene-Related Peptide (CGRP)
Vol 36, Issue 6, 2022
Abstract
Background: This study determined the function and the underlying mechanism of fibulin-5 in patients with lung infections. Methods: Serum was collected from patients with lung infections and healthy volunteers. Mice underwent cecal ligation and puncture surgery as served as a lung infection model. Serum expression of fibulin-5 was downregulated in patients and mice with lung infections. Results: Fibulin-5 attenuated inflammation and prevented lung injury in mice with lung infections via suppression of the calcitonin gene-related peptide (CGRP) pathway. Upregulation of fibulin-5 attenuated inflammation and suppressed the CREB/CGRP pathway in an in vitro model. Upregulation of the CREB/CGRP pathway weakened the anti-inflammation effects of fibulin-5 in an infection—induced lung injury model. These data demonstrated, for the first time, that serum fibulin-5 gene expression may be a clinical indicator in patients with lung infections. Conclusions: Furthermore, fibulin-t attenuated inflammation via the CREB/CGRP pathway.
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Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy