The Relation between microRNA-16 and Cardiac Remodelling Induced by Acute Myocardial Infarction: A Case Control Study

Abstract

Background: Adverse cardiac remodelling is common after acute myocardial infarction (AMI), which is closely related to heart failure and poor prognosis. Understanding the mechanism and early prediction of adverse cardiac remodelling may be beneficial to AMI patients. This study examined the clinical role of micro ribonucleic acid 16 (microRNA-16, miR-16) in cardiac remodelling after AMI. Methods: The expression changes of miR-16 in response to AMI were determined in vitro, and the correlation between miR-16 expression levels and clinical features was analysed. The receiver operating curve (ROC) of miR-16, cardiac troponin I (cTnI), and N-terminal pro-B-type natriuretic peptide (N-pro BNP) were plotted to predict their association with cardiac remodelling. Results: The expression level of miR-16 was significantly upregulated in response to AMI in vitro. The expression of miR-16 was positively correlated with N-pro BNP, left atrial diameter (LAD), interventricular septal thickness at diastole (IVSd), left ventricular posterior wall (LVPW) at the end of diastole, and left ventricular end-diastolic dimension (LVEDD), and negatively correlated with ejection fraction (EF). The areas under the ROC curve (AUC) of miR-16, troponin, and N-pro BNP in predicting cardiac remodelling were 0.81 (p < 0.001), 0.63 (p < 0.05), and 0.87 (p < 0.001), respectively. Conclusions: The results suggested that the miR-16 upregulation in AMI patients was a part of cardiac remodelling mechanism.