Analysis of the Predictive Value of Tumor Neutrophil-Associated Signature in Breast Cancer

Xia Lin; Shufang Hu; Honggang Chen

doi:10.23812/j.biol.regul.homeost.agents.20223604.109

Publication Frequency

Quarterly since 2025

Journal Articles

Search scope

Journal Center

Asia Pacific Academy of Science Pte. Ltd. (APACSCI) specializes in international journal publishing. APACSCI adopts the open access publishing model and provides an important communication bridge for academic groups whose interest fields include engineering, technology, medicine, computer, mathematics, agriculture and forestry, and environment.

more

Volume Arrangement

2025

Vol 39, No 3 (2025)

Vol 39, No 2 (2025)

Vol 39, No 1 (2025)

Featured Articles

Macrophages in the pathogenesis of psoriasis and anti-psoriatic nanotherapies

Psoriasis is a common, chronic, and inflammatory skin disease. Macrophages account for about 61.3% of the inflammatory cells infiltrating psoriatic lesions. Modulating macrophage polarization, inhibiting their infiltration, and targeting the secretion of inflammatory factors and associated inflammatory pathways by these cells can alleviate psoriasis symptoms and inflammation. Moreover, nanomaterials as novel drug carriers, offer unique advantages such as large surface area, easy modification, high biocompatibility, good biodegradability, enhanced systemic adsorption, etc. Nanomaterials have great potential for efficient drug delivery and release, as well as improving therapeutic efficacy while reducing adverse effects. By systematically addressing the role of macrophages in psoriasis pathogenesis and the potential of nanomaterials in treating psoriasis through modulating macrophages, this review enhances our understanding of the disease mechanism and holds promise for novel therapeutic breakthroughs and advancements in the future treatment of psoriasis.

Analysis of the Predictive Value of Tumor Neutrophil-Associated Signature in Breast Cancer

Xia Lin, Shufang Hu, Honggang Chen

Article ID: 6955
Vol 36, Issue 4, 2022

DOI: https://doi.org/10.23812/j.biol.regul.homeost.agents.20223604.109

Received: 8 September 2022; Accepted: 8 September 2022; Available online: 8 September 2022; Issue release: 8 September 2022

Abstract

Background: Neutrophils have both anti-tumor and pro-tumor effects. The aim of this study was to explore the predictive value of tumor neutrophil-related genes for breast cancer prognosis. Methods: Data of BC (breast cancer) patients were obtained from the public database (TCGA (The Cancer Genome Atlas)) to build a multigene prognostic signature. The results of patients between high- and low-risk groups were compared. The immune cell infiltration score was evaluated. Results: Eleven tumor neutrophil-related genes (RBFA, GOSR2, GPSM3, DHRS7, TSC22D4, RAC2, RBCK1, ATP6V0D1, TMEM14C, LCP1, UNC93B1) were obtained to construct the signature, which was named TAN1 (tumor-associated neutrophils)-11. This enabled dividing patients into two groups (high and low-risk groups). Patients with higher risk scores had poorer outcomes. The findings indicated that TANI-11 is an independent risk factor for prognosis. Higher risk score levels were positively associated with lymph node metastasis. In addition, TAN1-11 strongly was connected with immune infiltration like macrophage M0 & M2 (macrophages M0 and macrophages M2), resting natural killer cells, and neutrophils. This may affect the immunother-apeutic effect of the tumor. Conclusions: A valid signature was first reported as associated with tumor neutrophils in breast cancer. The value of this signature in indicating the prognosis of breast cancer patients may make it of value in guiding breast cancer immunotherapy.

Keywords

breast cancer (BC);gene signature;tumor neutrophils;overall survival (OS);TAN1-11;tumor microenvironment

References

Supporting Agencies

This site is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

Editor-in-Chief

Dr. Fabio Malavasi

Medical Genetics, University of Torino Medical School, Italy

Co-Editor-in-Chief

Prof. Marcello Iriti

Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy

Indexing & Archiving

News & Announcements

2025-02-01

Notice of Change in Publication Schedule

In addition to the first issue that has already been published by the original publisher, there will be four more issues released this year, with scheduled publication dates in March, June, September, and December respectively.

2025-01-21

Notice: Ownership Transfer of the Journal

Starting from Volume 39 Issue 2 (2025), the ownership of Journal of Biological Regulators and Homeostatic Agents (ISSN: 0393-974X (P); 1724-6083 (O)) will be transferred from Biolife Sas to Asia Pacific Academy of Science Pte. Ltd. As of 21 January 2025, authors should make submissions to the new journal system and follow the author guidelines. Asia Pacific Academy of Science Pte. Ltd. will take over the publication of manuscripts being processed.

More Announcements...