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Research Progress on the Mechanism of Vitamin D3 in the Occurrence and Development of Nonalcoholic Fatty Liver Disease
Vol 36, Issue 4, 2022
Abstract
Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases. Although the global incidence has been increasing in the recent years, the targeted treatment drugs remain unavailable. Recent studies have shown that vitamin D3 participates in fat metabolism, reduces insulin resistance, and has certain anti-oxidative, anti-apoptotic, anti-inflammatory, and anti-fibrotic properties. 25(OH)D is the active form of VD3. In the recent epidemiological studies, we observed lower serum 25(OH)D levels in patients with non-alcoholic fatty liver disease. Vitamin D3 supplementation can have some preventive effect on NAFLD occurrence and development. This article reviews the research progress and mechanisms of vitamin D3 action in NAFLD.
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Copyright (c) 2022 Liu Yang, Meng-Ting Zhou, Xiao-Chen Lu, Hai-Yang Zhu, Hong-Mei Han
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Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy