The Value of Asprosin on the Development in Prediabetic Individuals: A Prospective Study

Abstract

Background: A asprosin and Meteorin-like (Metrnl) are related to diabetic. The aim of this study was to assess the impact of asprosin or Metrnl on the development of diabetes in pre-diabetics. Methods: This is a prospective study. Subjects were divided into two groups: Impaired glucose tolerance (IGT) and impaired fasting glucose (IFG) based on the results of an oral glucose tolerance test. Two years later, subjects were divided into three groups based on blood glucose outcome: Normal, pre-diabetic and diabetic groups. Biochemical methods were used to detect blood glucose, blood lipids, liver function, kidney function and thyroid function. Radioimmunoassay was used to detect tumor markers. The levels of Asprosin and Metrnl were detected by ELISA (enzyme-linked immunosorbent assay). Results: A total of 403 subjects were enrolled in this study. At baseline, fasting blood glucose (FBG) and triglyceride (TG) were higher as well as 2-h postprandial blood glucose (PBG) and high-density lipoprotein (HDLC) were lower in IGT group than in IFG group (p < 0.05). Two years later, glycation hemoglobin (HbA1c), FBG, PBG, TG, kidney function related indexes creatinine (CREA) and Asprosin were lower while CHOL (total cholesterol) and HDLC were higher in prediabetic group than in diabetic group (p < 0.05). Asprosin and not Metrnl, positively correlated with HbA1c, PBG and CREA in diabetic patients (p < 0.001). Conclusions: Asprosin is related to blood glucose levels and markers of renal function in patients with diabetes.