High RBMS1 Predicts Poor Prognosis in Patients with Diabetes Mellitus

Abstract

Background and Objective: Diabetes mellitus (DM) might lead to dysfunctions in the kidney, retina, cardiovascular system, neurons and liver. Hence, identifying diagnostic biomarkers for diabetic complications is vital to improve the prognosis. The present study determines the association between RNA binding motif single stranded interacting protein 1 (RBMS1) and the prognosis of DM patients. Methods: This prospective observational study enrolled 190 patients with type 2 diabetes (T2DM), who underwent bariatric surgery from June 2015 to December 2021. In addition, 100 healthy individuals were enrolled as control subjects. Then, the serum level of RBMS1, fibroblast growth factor 21 (FGF-21), glucagon-like peptide-1 (GLP-1), and omentin were measured using enzyme-linked immunosorbent assay (ELISA) at baseline (0 days) and at 14 days post-surgery. The demographic characteristics, risk factors for coronary heart disease (CHD), and biochemical indexes of all participants were included for the present study. The receiver operating characteristic (ROC) curve was drawn to determine the diagnostic value of RBMS1 for CHD in T2DM patients. Then, the correlations among RBMS1, FGF-21, GLP-1 and omentin were analyzed using Spearman’s correlation analysis. Results: The serum level of RBMS1 was higher in T2DM patients, especially patients with CHD, when compared to control subjects. Furthermore, high RBMS1 level was associated with risk factors for CHD. The serum level of RBMS1 decreased after the surgery. A positive correlation was observed between RBMS1 and FGF-21, and a negative correlation was observed between RBMS1, and GLP-1 and omentin in T2DM patients. Therefore, high RBMS1 levels can predict the poor prognosis of T2DM patients. Conclusions: RBMS1 is associated with the prognosis and incidence of CHD in DM patients.