Prognostic Biomarkers and Molecular Mechanisms for Thoracic Aortic Aneurysms

Jian Ding; Tianxing Ni

doi:10.23812/j.biol.regul.homeost.agents.20223603.68

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Asia Pacific Academy of Science Pte. Ltd. (APACSCI) specializes in international journal publishing. APACSCI adopts the open access publishing model and provides an important communication bridge for academic groups whose interest fields include engineering, technology, medicine, computer, mathematics, agriculture and forestry, and environment.

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2025

Vol 39, No 3 (2025)

Vol 39, No 2 (2025)

Vol 39, No 1 (2025)

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Macrophages in the pathogenesis of psoriasis and anti-psoriatic nanotherapies

Psoriasis is a common, chronic, and inflammatory skin disease. Macrophages account for about 61.3% of the inflammatory cells infiltrating psoriatic lesions. Modulating macrophage polarization, inhibiting their infiltration, and targeting the secretion of inflammatory factors and associated inflammatory pathways by these cells can alleviate psoriasis symptoms and inflammation. Moreover, nanomaterials as novel drug carriers, offer unique advantages such as large surface area, easy modification, high biocompatibility, good biodegradability, enhanced systemic adsorption, etc. Nanomaterials have great potential for efficient drug delivery and release, as well as improving therapeutic efficacy while reducing adverse effects. By systematically addressing the role of macrophages in psoriasis pathogenesis and the potential of nanomaterials in treating psoriasis through modulating macrophages, this review enhances our understanding of the disease mechanism and holds promise for novel therapeutic breakthroughs and advancements in the future treatment of psoriasis.

Prognostic Biomarkers and Molecular Mechanisms for Thoracic Aortic Aneurysms

Jian Ding, Tianxing Ni

Article ID: 6894
Vol 36, Issue 3, 2022

DOI: https://doi.org/10.23812/j.biol.regul.homeost.agents.20223603.68

Received: 9 July 2022; Accepted: 9 July 2022; Available online: 9 July 2022; Issue release: 9 July 2022

Abstract

Background: Thoracic aortic aneurysm (TAA) is a fatal condition result from weakening of the thoracic aorta wall. This study aims to reveal promising prognostic biomarkers and the potential molecular mechanism associated with TAA. Method: The differentially expressed genes (DEGs) were explored between TAA samples (TAA group) and normal samples (control group). The enrichment analysis and protein-protein interaction (PPI) network analysis for DEGs were performed to explore diagnostic hub genes. The receiver operating characteristic curve (ROC) analysis was performed on each hub gene to evaluate the diagnostic effect of hub genes. Finally, the associations of hub gene with immune cells were investigated. Result: A total of 702 DEGs were revealed between TAA and control groups. These DEGs such as FOXP3 were mainly assembled in functions like regulation of cell adhesion. PPI network analysis explored 20 hub genes including CCL19, SOCS3, and IL10. Moreover, compared with normal samples, the cell infiltration in monocytes was significant in TAA samples. Finally, the correlation analysis between hub genes and immune cells showed that monocytes were negatively correlated with hug genes including IL7R. Conclusions: A total of 20 hub genes including CCL19 and IL10 were revealed as potential diagnostic biomarkers for TAA. FOXP3 might take part in the progression of TAA via regulating cell adhesion. Furthermore, the inhibition of monocytes via promoting IL7R expression may contribute to the clinical treatment of TAA.

Keywords

thoracic aortic aneurysm;differentially expressed genes;prognostic biomarkers;enrichment analysis;immune cell infiltration

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Dr. Fabio Malavasi

Medical Genetics, University of Torino Medical School, Italy

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Prof. Marcello Iriti

Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy

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2025-02-01

Notice of Change in Publication Schedule

In addition to the first issue that has already been published by the original publisher, there will be four more issues released this year, with scheduled publication dates in March, June, September, and December respectively.

2025-01-21

Notice: Ownership Transfer of the Journal

Starting from Volume 39 Issue 2 (2025), the ownership of Journal of Biological Regulators and Homeostatic Agents (ISSN: 0393-974X (P); 1724-6083 (O)) will be transferred from Biolife Sas to Asia Pacific Academy of Science Pte. Ltd. As of 21 January 2025, authors should make submissions to the new journal system and follow the author guidelines. Asia Pacific Academy of Science Pte. Ltd. will take over the publication of manuscripts being processed.

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