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ATOPIC DERMATITIS: EXPRESSION OF IMMUNOLOGICAL IMBALANCE
Vol 29, Issue 2S1, 2015
Abstract
Atopic dermatitis is a chronic relapsing-remitting inflammatory skin condition, characterized by a skin barrier dysfunction resulting in epidermal damage and altered permeability to allergens and microbes. Although pathogenesis of atopic dermatitis is complex and still not fully understood, it has been hypothesized that genetic predisposition, environmental factors, and skin barrier dysfunction are involved. Innate and adaptive immune system has also a pivotal role in the development, maintenance and flare-up of atopic dermatitis. The immune-pathogenesis of atopic dermatitis is determined by the impairment of different T helper cells, of their cytokine secretion profiles as well as of their specific receptor. In this review, we focus on the current knowledge of the etiopathogenetic pathways of atopic dermatitis in relationship to the critical role of the innate and adaptive immune system, providing a unifying view.
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Copyright (c) 2015 S Manti, R Chimenz, A Salpietro, L Colavita, P Pennisi, C Pidone, M Sturiale, T Arrigo, M Miraglia Del Giudice, C Salpietro, C Cuppari
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Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy