The meniscus vascularization: the direct correlation with tissue composition for tissue engineering purposes

A Di Giancamillo, L Mangiavini, I Tessaro, A Marmotti, R Scurati, G M Peretti

Article ID: 6610
Vol 30, Issue 4S1, 2016
DOI: https://doi.org/10.54517/jbrha6610
Received: 8 January 2017; Accepted: 8 January 2017; Available online: 8 January 2017; Issue release: 8 January 2017

Abstract

Meniscal lesions still represent an unsolved problem in clinical practice. Like the articular cartilage, meniscus has a scarce healing potential. Thus, when this tissue is damaged, the joint biomechanics is completely altered, leading to the development and progression of premature osteoarthritis. Therefore, in the last years, several tissue-engineering strategies have been developed to regenerate the meniscus with debated results. The comprehension of complex processes underlying meniscus maturation and structure is essential for a correct approach for the generation of a biomimetic meniscal substitute. In this chapter, we will first review the morphology of the meniscus during growth, focusing on the unique pattern of vascularization, and then we will discuss the most common tissue engineering strategies for meniscus repair.


Keywords

meniscus;vascularization;tissue engineering;animal models


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