Evaluation of the intraepithelial papillary capillary loops in benign and malignant oral lesions by in vivo Virtual Chromoendoscopic Magnification: a preliminary study

M Contaldo, A Lucchese, E Gentile, C Zulli, M Petruzzi, D Lauritano, M R Amato, P Esposito, G Riegler, R Serpico

Article ID: 6551
Vol 31, Issue 2S1, 2017
DOI: https://doi.org/10.54517/jbrha6551
Received: 9 July 2017; Accepted: 9 July 2017; Available online: 9 July 2017; Issue release: 9 July 2017

Abstract

This preliminary study aims to establish the Virtual Chromoendoscopic Magnification (VCM) feasibility to visualize and distinguish the Intraepithelial Papillary Capillary Loops (IPCL) patterns of benign oral pathologies from malignant ones. Thirty-one consecutive subjects affected by oral lesions/pathologies underwent white light examination and VCM imaging by the Narrow Band Imaging System (Olympus Medical Systems Corp., Tokyo, Japan). A class system of four IPCL types corresponding to progressive vessel disarray was adopted. IPCL type IV were considered criterion of "malignancy". A histopathological exam completed the diagnosis: sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy were calculated. IPCL patterns of benign oral entities ranged from types I to III. IPCL type IV was associated with malignancy in 4 out of 6 cases. Sensitivity, specificity, PPV, and NPV were 100%, 93%, 67% and 100%, respectively. This study preliminarily describes IPCL patterns of different oral mucosal diseases and confirms the association between IPCL IV and oral cancer.


Keywords

virtual chromoendoscopic magnification;narrow band imaging;oral cancer;oral pathology;non-invasive imaging


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