CORRELATION BETWEEN GAMMA GLUTAMYLTRANSFERASE FRACTIONS AND BONE QUALITY

M. FRANZINI; A. NESTI; D. PANETTA; V. FIERABRACCI; S. MARCHETTI; P.D. PARCHI; L. CAPONI; A. PAOLICCHI; V. MUSETTI; P. SALVADORI; M. EDMIN; A. PUCCI; E. BONICOLI; M. SCAGLIONE; N. PIOLANTI

doi:10.54517/jbrha6548

Publication Frequency

Quarterly since 2025

Journal Articles

Search scope

Journal Center

Asia Pacific Academy of Science Pte. Ltd. (APACSCI) specializes in international journal publishing. APACSCI adopts the open access publishing model and provides an important communication bridge for academic groups whose interest fields include engineering, technology, medicine, computer, mathematics, agriculture and forestry, and environment.

more

Volume Arrangement

2025

Vol 39, No 3 (2025)

Vol 39, No 2 (2025)

Vol 39, No 1 (2025)

Featured Articles

Macrophages in the pathogenesis of psoriasis and anti-psoriatic nanotherapies

Psoriasis is a common, chronic, and inflammatory skin disease. Macrophages account for about 61.3% of the inflammatory cells infiltrating psoriatic lesions. Modulating macrophage polarization, inhibiting their infiltration, and targeting the secretion of inflammatory factors and associated inflammatory pathways by these cells can alleviate psoriasis symptoms and inflammation. Moreover, nanomaterials as novel drug carriers, offer unique advantages such as large surface area, easy modification, high biocompatibility, good biodegradability, enhanced systemic adsorption, etc. Nanomaterials have great potential for efficient drug delivery and release, as well as improving therapeutic efficacy while reducing adverse effects. By systematically addressing the role of macrophages in psoriasis pathogenesis and the potential of nanomaterials in treating psoriasis through modulating macrophages, this review enhances our understanding of the disease mechanism and holds promise for novel therapeutic breakthroughs and advancements in the future treatment of psoriasis.

CORRELATION BETWEEN GAMMA GLUTAMYLTRANSFERASE FRACTIONS AND BONE QUALITY

M. FRANZINI, A. NESTI, D. PANETTA, V. FIERABRACCI, S. MARCHETTI, P.D. PARCHI, L. CAPONI, A. PAOLICCHI, V. MUSETTI, P. SALVADORI, M. EDMIN, A. PUCCI, E. BONICOLI, M. SCAGLIONE, N. PIOLANTI

Article ID: 6548
Vol 31, Issue 4S1, 2017

DOI: https://doi.org/10.54517/jbrha6548

Received: 8 January 2018; Accepted: 8 January 2018; Available online: 8 January 2018; Issue release: 8 January 2018

Abstract

Gamma-glutamyltransferase (GGT) has been recently identified as a bone-resorbing factor. The aimof this study was to investigate the association between plasma GGT fractions levels and bone quality.Plasma GGT fractions were analysed by gel-filtration chromatography. Bone quality was establishedquantitatively by two micro-CT derived microarchitectural parameters: the BV/TV (mineralised bonevolume/total volume), and the SMI (structure model index) that describes the rod-like (low resistant) orplate-like (high-resistant) shape of bone trabeculae. We enrolled 93 patients hospitalised for elective totalhip replacement (group Arthrosis, n=46) or for proximal femoral fracture (group Fracture, n=47). Patientswithin the first quartile of BV/TV (Q1, osteoporotic patients, n=6) showed higher levels of b-GGT fraction[median (min-max): 3.37 (1.42–6.81)] compared to patients with normal bone density (fourth quartileQ4, n=10; 1.40 (0.83–4.36); p=0.0393]. Also, according to SMI, b-GGT value was higher in the subgroupwith bone fragility [Q1, n=8: 1.36 (0.43–4.36); Q4, n=8: 5.10 (1.4 –7.60); p=0.0117]. In conclusion, patientscharacterised by fragile bone structure showed specifically higher levels of plasma b-GGT activity thussuggesting fractional GGT analysis as a possible biomarker in the diagnosis of osteoporosis.

Keywords

Osteoporosis;gamma-glutamyltransferase;GGT fraction;micro-CT;biomarker

References

Supporting Agencies

Copyright (c) 2017 M. FRANZINI, A. NESTI, D. PANETTA, V. FIERABRACCI, S. MARCHETTI, P.D. PARCHI, L. CAPONI, A. PAOLICCHI, V. MUSETTI, P. SALVADORI, M. EDMIN, A. PUCCI, E. BONICOLI, M. SCAGLIONE, N. PIOLANTI

This site is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

Editor-in-Chief

Dr. Fabio Malavasi

Medical Genetics, University of Torino Medical School, Italy

Co-Editor-in-Chief

Prof. Marcello Iriti

Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy

Indexing & Archiving

News & Announcements

2025-02-01

Notice of Change in Publication Schedule

In addition to the first issue that has already been published by the original publisher, there will be four more issues released this year, with scheduled publication dates in March, June, September, and December respectively.

2025-01-21

Notice: Ownership Transfer of the Journal

Starting from Volume 39 Issue 2 (2025), the ownership of Journal of Biological Regulators and Homeostatic Agents (ISSN: 0393-974X (P); 1724-6083 (O)) will be transferred from Biolife Sas to Asia Pacific Academy of Science Pte. Ltd. As of 21 January 2025, authors should make submissions to the new journal system and follow the author guidelines. Asia Pacific Academy of Science Pte. Ltd. will take over the publication of manuscripts being processed.

More Announcements...