AUTOLOGOUS LIPOTRANSFER VERSUS STROMAL VASCULAR FRACTION ENRICHED LIPOINJECTION FOR DIABETIC FOOT WOUNDS HEALING: A PILOT STUDY

G. VICENTI; G. SOLARINO; v. PESCE; L. MORETTI; A. NOTARNICOLA; M. CARROZZO; F. RIFINO; B. MORETTI

doi:10.54517/jbrha6530

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Asia Pacific Academy of Science Pte. Ltd. (APACSCI) specializes in international journal publishing. APACSCI adopts the open access publishing model and provides an important communication bridge for academic groups whose interest fields include engineering, technology, medicine, computer, mathematics, agriculture and forestry, and environment.

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Macrophages in the pathogenesis of psoriasis and anti-psoriatic nanotherapies

Psoriasis is a common, chronic, and inflammatory skin disease. Macrophages account for about 61.3% of the inflammatory cells infiltrating psoriatic lesions. Modulating macrophage polarization, inhibiting their infiltration, and targeting the secretion of inflammatory factors and associated inflammatory pathways by these cells can alleviate psoriasis symptoms and inflammation. Moreover, nanomaterials as novel drug carriers, offer unique advantages such as large surface area, easy modification, high biocompatibility, good biodegradability, enhanced systemic adsorption, etc. Nanomaterials have great potential for efficient drug delivery and release, as well as improving therapeutic efficacy while reducing adverse effects. By systematically addressing the role of macrophages in psoriasis pathogenesis and the potential of nanomaterials in treating psoriasis through modulating macrophages, this review enhances our understanding of the disease mechanism and holds promise for novel therapeutic breakthroughs and advancements in the future treatment of psoriasis.

AUTOLOGOUS LIPOTRANSFER VERSUS STROMAL VASCULAR FRACTION ENRICHED LIPOINJECTION FOR DIABETIC FOOT WOUNDS HEALING: A PILOT STUDY

G. VICENTI, G. SOLARINO, v. PESCE, L. MORETTI, A. NOTARNICOLA, M. CARROZZO, F. RIFINO, B. MORETTI

Article ID: 6530
Vol 31, Issue 4S1, 2017

DOI: https://doi.org/10.54517/jbrha6530

Received: 8 January 2018; Accepted: 8 January 2018; Available online: 8 January 2018; Issue release: 8 January 2018

Abstract

Chronic ulcers of the lower limbs represent a significant social and economic burden. Diabetes isa strong risk factor for development of chronic lesions. Adult stem cells and growth factors derivedfrom the adipose tissue are among the most promising therapeutic strategies for hard to heal wounds.Fat grafts have been used for several decades to treat soft tissue deformities, but despite its excellentcharacteristics, the outcome was unpredictable, due to partial necrosis and resorption of the graft. Stemcells’ enrichment of these grafts or their injection into the edges of the ulcers have shown encouragingresults in various experimental settings. In this pilot study, we compared the standard of care toautologous lipotransfer and stromal vascular fraction (SVF) enriched lipoinjection in 30 patients withdiabetic foot ulcers, showing clear superiority of SVF enriched lipoinjection in terms of percentage ofreduction of ulcers size and healing time.

Keywords

stem cells;chronic ulcers;regenerative medicine;adipose tissue;stromal vascular fraction;autologous lipotransfer

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Medical Genetics, University of Torino Medical School, Italy

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Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy

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2025-01-21

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