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HISTOLOGICAL CHANGES OF THE MENISCUS FOLLOWING AN OSTEOCHONDRAL LESION
Vol 31, Issue 4S1, 2017
Abstract
In the last few years, different tissue engineering strategies have been developed for the repair ofosteochondral lesions. When the osteochondral scaffold is implanted on the femoral condyle, themeniscus might be affected by the implant and might undergo a progressive degeneration. The aim ofour study is to analyze the morphological changes of the meniscus following an osteochondral lesion andthe implant of a biphasic scaffold. A critical osteochondral defect was generated in the medial femoralcondyle of mature sheep. Three defects were left untreated, the remaining lesions were divided intothree groups and treated with a biphasic substituted formed by collagen type I and Wollastonite orWollastonite/Hydroxyapatite. Animals were sacrificed after 6 months and menisci were isolated andanalyzed by arthro-CT, macroscopic evaluation and histology. The results demonstrated that theosteochondral lesion negatively affects meniscus morphology and that the osteochondral substitute onlypartially mitigates the meniscus degeneration.
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Copyright (c) 2017 G.M. PERETTI, I. TESSARO, L. MONTANARI, U. POLITO, A. DI GIANCAMILLO, M. DI GIANCAMILLO, A. MARMOTTI, A. MONTARULI, E. ROVEDA, L. MANGIAVINI
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Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy