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THE EFFECT OF ANTI-IGE THERAPY IN KNEE OSTEOARTHRITIS: A PILOT OBSERVATIONAL STUDY
Vol 31, Issue 4S1, 2017
Abstract
Osteoarthritis is a whole-joint disease and its pathogenesis remains poorly understood. Recentevidence proposed the importance of the innate immune system as trigger of synovium inflammationfollowing the degeneration of cartilage. Moreover, synovial mast cells (MCs) might be correlated withpain and disability reported by patients. Anti IgE therapy represents a new class of MCs stabilizingagent, licensed for people with asthma and chronic urticaria. Therefore, we studied if the stabilizingeffect of anti IgE would improve the pain and disability in patients affected by knee osteoarthritis andatopic disease. This pilot study provides the first evidence that anti IgE treatment induces a short-termclinical improvement supporting the role of MCs in osteoarthritis.
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Copyright (c) 2017 A. AQUILI, L. FARINELLI, C. BOTTEGONI, L. ANTONICELLI, A. GIGANTE
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Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy