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ROLE OF FUSOBACTERIUM NUCLEATUM IN INTESTINAL TUMORIGENESIS
Vol 32, Issue 4S1, 2018
Abstract
Colorectal cancer is one of the most common malignant tumors and an important associated-factoris intestinal microbiota. This may enhance the carcinogenicity by proliferation and differentiation ofepithelial cells and by decreasing immune response to pathogenic organisms. The aim of the study isto analyze the link between the presence of Fusobacterium nucleatum (FN) in a series of matched oralbrushing, colon adenomas/carcinomas and adjacent mucosa, and finally to elucidate the FN disseminationmechanism from oral cavity to colon. FN is detected in saliva, especially in smokers, with its quantitiesincreased in patients with gingivitis and periodontitis, compared to the healthy controls.
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Supporting Agencies
Copyright (c) 2018 P. PIGNATELLI, P. RAIMONDI, C. CELLINI, A. CICHELLA, R. GRANDE, A. RICCI, A. GENTILE, R. COTELLESE, A. PIATTELLI, M.C. CURIA
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Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy