RETINOIC ACID INDUCED DIFFERENTIATION MODIFIES HO-1 DEPENDENT NEUROBLASTOMA RESPONSE TO OXIDATIVE STRESS

L. BRONDOLO

doi:10.54517/jbrha6502

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Macrophages in the pathogenesis of psoriasis and anti-psoriatic nanotherapies

Psoriasis is a common, chronic, and inflammatory skin disease. Macrophages account for about 61.3% of the inflammatory cells infiltrating psoriatic lesions. Modulating macrophage polarization, inhibiting their infiltration, and targeting the secretion of inflammatory factors and associated inflammatory pathways by these cells can alleviate psoriasis symptoms and inflammation. Moreover, nanomaterials as novel drug carriers, offer unique advantages such as large surface area, easy modification, high biocompatibility, good biodegradability, enhanced systemic adsorption, etc. Nanomaterials have great potential for efficient drug delivery and release, as well as improving therapeutic efficacy while reducing adverse effects. By systematically addressing the role of macrophages in psoriasis pathogenesis and the potential of nanomaterials in treating psoriasis through modulating macrophages, this review enhances our understanding of the disease mechanism and holds promise for novel therapeutic breakthroughs and advancements in the future treatment of psoriasis.

RETINOIC ACID INDUCED DIFFERENTIATION MODIFIES HO-1 DEPENDENT NEUROBLASTOMA RESPONSE TO OXIDATIVE STRESS

L. BRONDOLO

Article ID: 6502
Vol 32, Issue 4S1, 2018

DOI: https://doi.org/10.54517/jbrha6502

Received: 8 September 2018; Accepted: 8 September 2018; Available online: 8 September 2018; Issue release: 8 September 2018

Abstract

The ability to counteract oxidative stress (OS) plays a pivotal role in neuronal survival. Thedifferentiation of neuroblastoma (NB) cells with retinoic acid (RA) generates a small amount of ROSinvolved in neurite elongation (Nitti, 2010). However, differentiated cells are more sensitive to the exposureto OS than undifferentiated ones (Piras, 2017). In the present study, we analyzed the behavior of two RAdifferentiatedNB cell lines, SH-SY5Y and SK-N-BE(2C) in response to OS. Furthermore, the regulation ofHO-1 expression has been analyzed evaluating Nrf2 as the main activator and Bach1 as negative regulator.

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Medical Genetics, University of Torino Medical School, Italy

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Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy

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