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AMORPHOUS SILICA NANOPARTICLES INTERFERE WITH LPS-DEPENDENT TRANSDUCTION OF INFLAMMATORY SIGNALS
Vol 32, Issue 4S1, 2018
Abstract
Besides the epithelial barriers, macrophages represent the first cells that interact with engineerednanomaterials (ENM) upon exposure. Many studies report that several ENM are able to triggermacrophage activation. However, possible interference of ENM with the effects of typical macrophageactivators, such as PAMPs, has been much less investigated thus far. In this study, we have used two wellcharacterized, food-grade nanoparticles of amorphous SiO2 (ASNP), the precipitated NM200 and thepyrogenic NM203, to assess their effects on LPS-dependent activation of human macrophage-like cells.
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Supporting Agencies
Copyright (c) 2018 M.G. BIANCHI, M. CHIU, G. TAURINO, E. BERGAMASCHI, O. BUSSOLATI
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Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy